Table 1 Activity of ceftobiprole and comparator antimicrobial agents when tested against Staphylococcus isolated from China (mg/L)

Methicillin-resistant Staphylococcus aureus (MRSA) (55)

 Ceftobiprole

0.25 – 2

1

2

0

100

 Linezolid

0.25 – 2

0.5

1

0

100

 Vancomycin

0.25 – 1

0.5

1

0

100

 Penicillin

4 – > 32

 > 32

 > 32

100

0

 Oxacillin

4 – > 4

 > 4

 > 4

100

0

 Ciprofloxacin

0.25 – > 32

1

 > 32

45.5

54.5

 Clindamycin

 ≤ 0.06 – > 128

 > 128

 > 128

76.4

23.6

 Erythromycin

0.125 – > 128

 > 128

 > 128

85.5

12.7

Methicillin-susceptible Staphylococcus aureus (MSSA) (55)

 Ceftobiprole

0.25 – 2

0.5

1

0

100

 Linezolid

0.25 – 1

0.5

1

0

100

 Vancomycin

0.25 – 1

0.5

1

0

100

 Penicillin

0.03 – > 32

8

32

85.5

14.5

 Oxacillin

 ≤ 0.25 – 1

 ≤ 0.25

0.5

0

100

 Ciprofloxacin

0.25 – 32

0.5

16

12.7

83.6

 Clindamycin

 ≤ 0.06 – > 128

0.125

 > 128

23.6

72.7

 Erythromycin

0.125 – > 128

 > 128

 > 128

56.4

43.6

Methicillin-resistant Coagulase negative Staphylococci (MRCNS) (40)

 Ceftobiprole

 ≤ 0.015 – 4

1

2

–

–

 Linezolid

0.5 – 4

1

1

0

100

 Vancomycin

0.5 – 2

1

2

0

100

 Penicillin

0.5 – > 32

16

 > 32

100

0

 Oxacillin

0.5 – > 4

4

 > 4

100

0

 Ciprofloxacin

0.125 – > 32

16

 > 32

77.5

17.5

 Clindamycin

 ≤ 0.06 – > 128

 ≤ 0.06

 > 128

40

57.5

 Erythromycin

 ≤ 0.06 – > 128

 > 128

 > 128

87.5

12.5

Methicillin-susceptible Coagulase negative Staphylococci (MSCNS) (40)

 Ceftobiprole

 ≤ 0.015 – 1

0.25

0.5

–

–

 Linezolid

0.5 – 2

0.5

1

0

100

 Vancomycin

0.5 – 2

1

2

0

100

 Penicillin

 ≤ 0.015 – > 32

0.25

8

65

35

 Oxacillin

 ≤ 0.25

 ≤ 0.25

 ≤ 0.25

0

100

 Ciprofloxacin

0.125 – 16

0.25

4

15

67.5

 Clindamycin

 ≤ 0.06 – > 128

 ≤ 0.06

 > 128

15

85

 Erythromycin

 ≤ 0.06 – > 128

64

 > 128

67.5

32.5