Insights on the performance of phenotypic tests versus genotypic tests for the detection of carbapenemase-producing Gram-negative bacilli in resource-limited settings

Kamel, Noha A.; Tohamy, Sally T.; Yahia, Ibrahim S.; Aboshanab, Khaled M.

doi:10.1186/s12866-022-02660-5

Table 3 Spearman correlation coefficient among all possible genotypes and phenotypes combinations

From: Insights on the performance of phenotypic tests versus genotypic tests for the detection of carbapenemase-producing Gram-negative bacilli in resource-limited settings

Sample 1	Sample 2	Correlation	95% CI for ρ
bla_VIM + bla_GIM + bla_NDM	MHT + BCT + EDTA	0.774	[64.0- 86.2]
bla_VIM + bla_NDM	MHT + EDTA	0.763	[62.5–85.5]
bla_VIM + bla_GIM + bla_NDM	EDTA + mCIM + MHT	0.736	[58.7–83.6]
bla_VIM + bla_NDM	EDTA	0.724	[0.57.1–82.8]
bla_VIM + bla_NDM	MHT + BCT + EDTA	0.718	[0.56.3–82.4]
bla_VIM + bla_GIM + bla_NDM	MHT	0.711	[54.8–0.82.1]
bla_VIM + bla_NDM	EDTA + mCIM + MHT	0.683	[51.6–0.80.0]
bla_VIM + bla_NDM	MHT	0.679	[50.7–80.0]
bla_VIM + bla_GIM + bla_NDM	BCT + EDTA	0.678	[50.9–79.7]
bla_VIM + bla_GIM + bla_NDM	MHT + BCT + EDTA + mCIM	0.653	[47.7–77.9]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	MHT	0.653	[47.3–78.1]
bla_VIM + bla_NDM	MHT + BCT + EDTA + mCIM	0.623	[43.8–75.7]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	MHT + EDTA	0.617	[43.1–75.3]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	EDTA + mCIM + MHT	0.61	[42.1–74.7]
bla_VIM + bla_NDM	Blue Carba + EDTA	0.607	[41.8–74.6]
bla_VIM + bla_NDM + bla_OXA−48	MHT	0.6	[40.4–74.3]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	MHT + BCT + EDTA	0.593	[40.1–73.5]
bla_VIM + bla_GIM	MHT + EDTA	0.581	[38.6–72.6]
bla_VIM + bla_GIM + bla_NDM	mCIM + EDTA	0.581	[38.6–72.6]
bla_VIM + bla_GIM	EDTA	0.577	[38.1–72.3]
bla_VIM + bla_NDM	MHT + BCT	0.559	[35.9–71.0]
bla_VIM + bla_GIM + bla_NDM	MHT + BCT	0.558	[35.8–70.9]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	MHT + BCT + EDTA + mCIM	0.558	[35.8–70.9]
bla_VIM + bla_GIM	MHT + BCT + EDTA	0.548	34.6–70.2]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	MHT + BCT	0.544	[34.1–69.8]
bla_VIM + bla_NDM + bla_OXA−48	EDTA + mCIM + MHT	0.541	[33.8–69.7]
bla_VIM + bla_NDM + bla_OXA−48	MHT + EDTA	0.533	[32.8–69.0]
bla_VIM + bla_NDM + bla_OXA−48	MHT + BCT + EDTA	0.524	[31.7–68.3]
bla_VIM + bla_NDM	mCIM + EDTA	0.523	[31.6–68.2]
bla_VIM + bla_NDM + bla_OXA−48	MHT + BCT	0.518	[31.0- 67.9)
bla _VIM	MHT + EDTA	0.517	[30.7–67.9]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	mCIM + MHT	0.515	[30.6–67.6]
bla_VIM + bla_GIM + bla_NDM + bla_OXA−48	EDTA	0.515	[30.7–67.7]
bla_VIM + bla_NDM + bla_OXA−48	MHT + BCT + EDTA + mCIM	0.509	[29.9–67.2]
bla _VIM	MHT + BCT + EDTA	0.502	[29.0- 66.8]

Bla_KPC, gene coded for Klebsiella pneumoniae carbapenemases (KPC); bla_NDM, a gene coded for New Delhi metallo-β-lactamase (NDM); imipenem-resistant Pseudomonas-type carbapenemases (IMP); bla_VIM, a gene coded for Verona integron-encoded metallo-β-lactamase (VIM); bla_GIM, a gene coded for German imipenemase and bla_OXA−48, oxacillinase (OXA-48-like) types. MHT, modified Hodge test, mCIM, modified carbapenem inactivation method, CDT, combined disk test by EDTA; BCT, blue-carba test

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