Zinc oxide nanoparticles reduce biofilm formation, synergize antibiotics action and attenuate Staphylococcus aureus virulence in host; an important message to clinicians

Table 5 Effect of ZnO-NPs, gentamicin and their combination on wound area

Mice group	Wound area (mm²)/ (% of wound contraction)
	Days post treatment
	Day zero	Day 3	Day 6	Day 10	Day 14
Control (Untreated mice)	72 mm²	72 mm²	72 mm²	70 mm²	64 mm²
ZnO-NPs treated mice	72 mm²	48 mm² (33.3%)	30 mm² (58.3%)	15 mm² (79.1%)	0 mm² (100%)^a
Gentamicin treated mice	72 mm²	45 mm² (37.5%)	25 mm² (65.3%)	10 mm² (86.1%)	0 mm² (100%)^a
ZnO-NPs + gentamicin treated mice	72 mm²	21 mm² (70.8%)	5 mm² (93%)	0 mm² (100%)^a	0 mm² (100%)^a

ISSN: 1471-2180