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Fig. 9 | BMC Microbiology

Fig. 9

From: Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro

Fig. 9

Safety assessment of metformin in combination with minocycline. A Hemolytic activity of minocycline to the RBCs in the absence or presence of metformin. Sheep blood cells were treated with combinations of minocycline (16–128 µg/mL) and metformin (0–80 mg/mL). The hemolytic activity of minocycline was less than 5% either alone or in combination with metformin. B In vitro mammalian toxicity of minocycline in combination with metformin in vero cells using CCK-8 assay. C In vitro mammalian toxicity of minocycline in combination with metformin in HEK-293 cells using CCK-8 assay. Metformin (≤ 20 mg/mL) combination with different concentration minocycline had no cytotoxicity to vero cells and HEK-293 cells. Cytotoxicity phenomenon were found when using metformin ≥ 40 mg/mL. The data shown here are mean ± SD of three replicates

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BMC Microbiology

ISSN: 1471-2180

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