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Fig. 6 | BMC Microbiology

Fig. 6

From: C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Fig. 6

N6/N6-COOH-miniPEG protected mice from lethal challenge with E. coli and S. pullorum. Survival of mice treated with N6 and N6-COOH-miniPEG in (A) E. coli and (B) S. pullorum lethal models. Mice were intraperitoneally injected with E. coli (1 × 109 CFU/mL) followed by N6, N6-COOH-miniPEG or PMB at 0.5 and 8 h; Mice were intraperitoneally injected with S. pullorum (5 × 107 CFU/mL) followed by N6, N6-COOH-miniPEG or CIP at 0.5 and 8 h. Survival rates were recorded for 7 days. Effects on the bacterial translocation. Bacteria were counted in the livers, spleens, kidneys and lungs of mice infected with (C) E. coli or (D) S. pullorum after treatment with N6 or N6-COOH-miniPEG. The untreated mice were used as the negative control. Data were expressed as mean ± SE (n = 3)

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BMC Microbiology

ISSN: 1471-2180

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