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Fig. 1 | BMC Microbiology

Fig. 1

From: C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Fig. 1

In vitro time/dose-dependent killing curves and toxicity of N6 and its N6-COOH-miniPEG. (A) Time-killing curves of peptides (1 × , 2 × , or 4 × MIC) against E. coli CVCC195. Negative control group (CK) is the bacteria solution with PBS instead of antimicrobial peptides. PMB was used as the positive control. (B) Time-killing curves of peptides (1 × , 2 × , or 4 × MIC) against S. pullorum CVCC533. PBS was used as the negative control. CIP was used as the positive control. (C) Dose-time curves of peptides against E. coli CVCC195. Results were given as mean ± SE (n = 3). (D) Dose-time curves of peptides against S. pullorum CVCC533. Results were given as mean ± SE (n = 3). (E) Hemolytic activity of peptides at different concentrations (0.5 – 128 μg/mL) against mouse erythrocytes. (F) Cytotoxicity of peptides toward RAW 264.7 cells

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BMC Microbiology

ISSN: 1471-2180

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