Fig. 3

BLSOM and histogram analysis of 15-mers. a BLSOM of 15-mers. The number of nodes was set as described in Fig. 2a. b Histogram of the increase/decrease level of each 15-mer frequency in the June population compared to the December population. The vertical axis shows normal numbers or logarithms (Log). Here, nonexistence in the logarithmic display is shown expediently as 0; the dark- and light-brown (blue) bars in the histogram indicate data showing the largest (the second largest) class of the increase/decrease, respectively. c Changes in the monthly occurrences of 15-mers and their heatmap patterns. (i) The upper and lower panels plot the monthly occurrences of 15-mers according to the elapsed month, which are related to the M1 ~ 4 mutations in Table 1 (see also Table S2) and indicated by dark and light brown in b, respectively. Since there is little difference among the sixty 15-mers, the relationship between each 15-mer and the colored symbol was not described. (ii) Heatmaps of four pairs of 15-mers with a one-base difference; the four in the upper and lower panels show heatmaps of the pre- and postmutation sequences. d (i) The upper and lower panels plot monthly occurrences of a group of fifteen 15-mers belonging to the second largest class specified by dark and light blue, respectively. Here, the pre- and postmutation 15-mers are plotted in the same figure: M5 and M7 mutations in Table 1. (ii) Heatmaps of two pairs of 15-mers with one-base differences are placed next to the corresponding time-series diagram