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Table 1 MIC and FICI results with the combinations of MIN and azoles against Scedosporium apiospermum

From: The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species

Strain MIC (ug/mL) for:
Agent alone Combination [A/B(ug/mL)] (FICI)
MIN ITR VOR POS MIN/ITR MIN/VOR MIN/POS
Scedosporium aurantiacum
(CBS 116910)
≥16 8 0.5 2 4/2(S) 4/0.25(I) 8/0.5(S)
Scedosporium minutispora
(CBS 116911)
≥16 2 0.25 2 4/0.25(S) 8/0.25(I) 8/0.5(S)
Scedosporium boydii
(CBS 101.22)
≥16 2 0.25 2 8/1(I) 16/0.25(I) 4/0.5(S)
Lomentospora prolificans
(CBS 467.74)
≥16 ≥16 16 ≥16 4/8(S) 4/8(I) 4/8(S)
Scedosporium dehoogii
(CBS 117406)
≥16 2 0.5 2 4/1(I) 4/0.5(I) 8/0.5(S)
Scedosporium apiospermum
(CBS 116899)
≥16 4 0.25 2 4/1(S) 4/0.25(I) 8/0.5(S)
Scedosporium boydii
(1)
>16 >16 1 2 8/1 (S) 8/0.25(I) 8/0.5(S)
Scedosporium boydii
(2)
>16 4 1 1 4/1(S) 8/0.25(I) 8/0.25(S)
Scedosporium boydii
(3)
>16 >16 1 4 8/2(S) 8/0.5(I) 8/1(S)
Scedosporium apiospermum
(4)
>16 >16 1 4 8/4(S) 8/0.25(I) 4/1(S)
Scedosporium apiospermum
(5)
>16 >16 1 2 8/4(S) 8/0.5(I) 8/0.5(S)
Scedosporium apiospermum
(6)
>16 >16 0.5 2 8/4 (S) 4/0.5 (I) 8/0.5(S)
Lomentospora prolificans
(7)
>16 >16 >16 >16 16/16(I) 16/16(I) 16/16(I)
Scedosporium minutisporum
(8)
>16 8 1 2 8/2(S) 8/0.25(S) 8/0.5(S)
Scedosporium apiospermum
(9)
>16 >16 0.5 4 8/16(I) 8/0.125(I) 8/1(S)
Scedosporium boydii
(10)
>16 4 0.25 1 4/1(S) 8/0.125 (I) 8/0.25(S)
  1. MIC is determined by the concentrations of drugs at which growth was completely inhibited. FICI results are shown in parentheses. S, synergistic effect (FICI of 0.5); I, no interaction (indifference) (0.5 FICI 4)