Intra-wound vancomycin powder for the eradication of periprosthetic joint infection after debridement and implant exchange: experimental study in a rat model

Table 2 Serum levels of vancomycin at 0.5, 2, 4 and 12 h after vancomycin treatment in each group (μg/ml)

Group	0.5 h	2 h	4 h	12 h
Control	0	0	0	0
SV	10.21 ± 1.79	3.32 ± 0.58	0.48 ± 0.03	#
VP	2.68 ± 0.32	0.71 ± 0.08	0.50 ± 0.04	#
SV&VP	14.14 ± 1.18	7.49 ± 0.62	1.40 ± 0.23	#

Control (no antibiotics); SV Systemic vancomycin (intraperitoneal injection, 88 mg/kg, every 12 h), VP Intra-wound vancomycin powder (before closure of the capsule, 88 mg/kg, single dosage), SV&VP Systemic vancomycin & intra-wound VP (intraperitoneal injection, 88 mg/kg, every 12 h; combined with intra-wound VP before closure of the capsule, 88 mg/kg, single dosage). n = 6. # Below the limit of detection (0.1 μg/ml)

ISSN: 1471-2180