|
Species
|
Isolate
|
MIC (mg/L)a
|
Amino acid change
|
Plasmid mediated resistance
|
|---|
|
MgrB
|
PmrB
|
PmrA
|
PmrC
|
PhoP
|
PhoQ
|
mcr
|
|---|
|
K. pneumoniae
|
404,507-16
|
≥64
|
D31N
|
L213M
|
A41T
| | |
S288N
| |
|
4,002,006-2
|
32
|
K3*
| | | | | | |
|
16,003,084
|
32
|
C28S
| |
A217V
|
G25S
| | | |
|
20,038,016
|
32
|
C39Y
| | | | | | |
|
808,927-16
|
32
|
L8*
| | |
R152H
| | | |
|
D477N
|
|
26,048,671
|
32
|
I41* (ISKpn26)b
| | | | | | |
|
800,138-16
|
32
|
I41* (ISEcp1)b
| | | | | | |
|
401,433-14
|
16
|
Q30*
| | | | | | |
|
802,208-17
|
16
|
L4*
| |
D149E
| | | | |
|
187,701,876
|
16
|
C39G
| | | | | | |
|
19,852,760
|
8
| | |
A217V
|
G25S
| | | |
|
809,156-16
|
4
| | |
D149E
| | | | |
|
E. coli
|
721,296-16
|
16
| |
P97L
| |
C27Y
| | | |
|
700,455-17
|
16
| |
L197D
| |
N12D
| | | |
|
709,006-16
|
16
| |
E169K
| | | | | |
|
705,963-16
|
16
| |
P97A
| | | | | |
|
700,099-17
|
8
| | | | | | |
mcr 1.1
|
|
706,090-16
|
8
| | |
R81H
|
Q479E
| | | |
|
NCTC-13846
|
8
| | | | | |
L467M
|
mcr 1.1
|
|
KP-37-MCR-2-18
|
8
| | | |
C27Y
| | |
mcr 2
|
|
L74I
|
|
707,671-17
|
8
| | | |
C27Y
| | | |
|
719,645-16
|
8
| | | | | | |
mcr 1.1
|
|
705,498-12
|
4
| | | | | | |
mcr 1.1
|
|
A. bereziniae
|
502,814-14
|
≥64
| |
Q242R
| | | | | |
- aMIC values obtained by the reference broth microdilution method
- bNucleotide sequence interrupted by insertion sequence. * indicates premature stop codons or termination in the amino acid sequence indicates premature stop codons or termination in the amino acid sequence
