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Table 3 Skin irritation tests of gelatin hydrogels containing paenipeptin analogue 1 and clarithromycin on CD-1 mice

From: Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Concentrationa (mg/ml) Number of mice with skin redness or rash after the treatment
24 h 48 h
0 0/6 0/6
0.1 0/6 0/6
0.2 0/6 0/6
0.4 0/6 4/6
  1. aPaenipeptin analogue 1 and clarithromycin were tested at a final concentration of 0, 0.1, 0.2 or 0.4 mg/ml for each compound in the hydrogels