Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Table 3 Skin irritation tests of gelatin hydrogels containing paenipeptin analogue 1 and clarithromycin on CD-1 mice

Concentration^a (mg/ml)	Number of mice with skin redness or rash after the treatment
Concentration^a (mg/ml)	24 h	48 h
0	0/6	0/6
0.1	0/6	0/6
0.2	0/6	0/6
0.4	0/6	4/6

^aPaenipeptin analogue 1 and clarithromycin were tested at a final concentration of 0, 0.1, 0.2 or 0.4 mg/ml for each compound in the hydrogels

ISSN: 1471-2180