Table 1 Minimum inhibitory concentration (MIC) of clarithromycin (CLR) with or without paenipeptin analogue 1 (Paen1) against 70 isolates in the Gram-Negative Carbapenemase Detection panel from the FDA-CDC Antibiotic-Resistance (AR) Bank
Species | No. of Isolates | MIC of Paen1 (μg/ml) | MIC of CLR (μg/ml) | MIC of CLR (μg/ml) (in the presence of Paen1 at 4 μg/ml) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Range | 50% | 90% | Range | 50% | 90% | Range | 50% | 90% | ||
A. baumannii | 14 | 2− > 32 | 32 | > 32 | 4− > 32 | 32 | > 32 | 0.0019 − 8 | 0.03125 | 8 |
E. cloacae | 9 | 4− > 32 | 16 | > 32 | > 32 | > 32 | > 32 | 0.0019 − 0.25 | 0.03125 | 0.25 |
E. coli | 13 | 4 − 32 | 16 | 32 | > 32 | > 32 | > 32 | 0.0019 − 0.0625 | 0.03125 | 0.0625 |
K. pneumoniae | 22 | 32− > 32 | > 32 | > 32 | > 32 | > 32 | > 32 | 0.03125 − 8 | 0.25 | 8 |
P. aeruginosa | 12 | 8− > 32 | 32 | 32 | > 32 | > 32 | > 32 | 16− > 32 | > 32 | > 32 |