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Table 1 Minimum inhibitory concentration (MIC) of clarithromycin (CLR) with or without paenipeptin analogue 1 (Paen1) against 70 isolates in the Gram-Negative Carbapenemase Detection panel from the FDA-CDC Antibiotic-Resistance (AR) Bank

From: Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Species No. of Isolates MIC of Paen1 (μg/ml) MIC of CLR (μg/ml) MIC of CLR (μg/ml)
(in the presence of Paen1 at 4 μg/ml)
Range 50% 90% Range 50% 90% Range 50% 90%
A. baumannii 14 2− > 32 32 > 32 4− > 32 32 > 32 0.0019 − 8 0.03125 8
E. cloacae 9 4− > 32 16 > 32 > 32 > 32 > 32 0.0019 − 0.25 0.03125 0.25
E. coli 13 4 − 32 16 32 > 32 > 32 > 32 0.0019 − 0.0625 0.03125 0.0625
K. pneumoniae 22 32− > 32 > 32 > 32 > 32 > 32 > 32 0.03125 − 8 0.25 8
P. aeruginosa 12 8− > 32 32 32 > 32 > 32 > 32 16− > 32 > 32 > 32