Table 1 Patterns and distribution of GyrA and ParC substitutions and PMQR in 149 clinical CRKP isolates
CIP (MIC) | Mutation | Carrying PMQR (frequency) | Frequency | MLST (number of isolates) |
|---|---|---|---|---|
S | No substitution | aac(6′)-Ib-cr (12); qnrS1(9); qnrB1 (1); aac(6′)-Ib-cr, qnrS1 (1); aac(6′)-Ib-cr, qnrS1, qnrB4 (1) | 31 | ST107 (1); ST1319 (2); ST2390 (1); ST290 (7); ST307 (3); ST35 (2); ST37 (1); ST375 (1); ST45 (12); ST462 (1) |
I | ParC-80I; GyrA-83I; GyrA-87G | qnrS1 (1) | 1 | ST11 (1) |
R | No substitution | aac(6′)-Ib-cr (1); qnrS1(1); qnrB4 (1); aac(6′)-Ib-cr, qnrS1 (1); aac(6′)-Ib-cr, qnrS1, qnrB2 (1) | 6 | ST1692 (2); ST290 (1); ST290 (1); ST2236 (1) |
R | ParC-80I; GyrA-83F; GyrA-87A | – | 4 | ST15 |
R | ParC-80I; GyrA-83F; GyrA-87A | aac(6′)-Ib-cr (2); qnrB4 (2): aac(6′)-Ib-cr, qnrS1, qnrB1 (1); aac(6′)-Ib-cr, qnrB2 (1) | 6 | ST15 (4); ST2237 (2) |
R | ParC-80I; GyrA-83I; GyrA-87G | – | 47 | ST11 (47) |
R | ParC-80I; GyrA-83I; GyrA-87G | qnrS1 (44); qnrB4 (3); aac(6′)-Ib-cr, qnrB1, qnrB4 (1) | 48 | ST11 (48) |
R | GyrA-83I; GyrA-87G | qnrS1 (1) | 1 | ST11 |
R | ParC-80I; GyrA-83I | aac(6′)-Ib-cr (1); qnrS1 (2); aac(6′)-Ib-cr, qnrS1, qnrB2, qnrB4 (1) aac(6′)-Ib-cr, qnrB2 (1) | 5 | ST438 (2); ST485 (1); ST11 (1); ST395 (1) |