A high-throughput screening assay based on automated microscopy for monitoring antibiotic susceptibility of Mycobacterium tuberculosis phenotypes

Table 1 IC₅₀ and MIC values for antibiotics (n = 3)

Antibiotic	IC₅₀ [µg/ml, (CI)]		MIC (CI)/Standard MIC [µg/ml]^**		Published MIC-ranges [µg/ml] [29, 30]
	Planktonic	Cording	Planktonic	Cording	H37Rv ATCC 27,294
Rifampicin	0.0013 (0.00083–0.0019)	0.00070 (0.00036–0.0013)	0.017 (0.0077–0.038)/0.016	0.0088 (0.0029-0.27)/0.016	0.06–0.25
Isoniazid	0.00074 (0.00031–0.0017)	0.00036 (6.9 × 10^− 5-0.00082)	0.0021 (0.00069–0.0067)/0.004	0.0028 (0.0011–0.0069)/0.004	0.03–0.06
Linezolid	0.36 (0.12–1.1)	0.15 (0.065–0.36)	1.7 (*)/2	1.1 (*)/1	0.25-1
Levofloxacin	0.29 (0.15–0.55)	0.23 (0.12–0.44)	1.1 (*)/1	0.91 (*)/1	0.25-1
Ethambutol	0.97 (0.19–5.3)	0.77 (0.11–5.5)	8.0 (*)/8	6.4 (*)/8	1–4
Clofazimine	0.28 (0.034-*)	0.081 (0.0018-*)	0.31 (0.018–5.28)/0.5	ND	0.12–0.5
Moxifloxacin	0,019 (*-0.063)	0,0037 (*-0.032)	ND	ND	0.06–0.25
Pretomanid	0,073 (*)	0,037 (*-0.17)	ND	ND	ID

ISSN: 1471-2180