Fig. 4

Significantly distinct Species in IDH and ISH as compared with controls. a Venn diagrams demonstrating the number of differential species on comparing control (con) and IDH, control, and ISH, respectively. The overlap identified 21 concurrently varied species; q<0.05 (P values were corrected using the Benjamini-Hochberg method, shown as q values), Wilcoxon rank-sum test. b Heat map showing the top 30 of the 389 altered species in IDH. The abundance profiles were expressed by Z scores. The Z score was negative (shown in blue) when the row abundance was lower than the mean and is shown in red when the row abundance was higher than the mean. c Heat map showing the top 30 of the 159 different species in control and ISH. d Scatter plots show the relative abundance of the top 10 species shared between control vs. IDH, and control vs. ISH. In order to show it clearly, the relative abundance of species-level was transformed into log10 values. Green, control; blue, ISH; and orange, IDH. The dots indicate individual values of the participants, and the horizontal lines from bottom to top represent 25th percentiles, medians, and 75th percentiles, respectively