Decreased abundance of Akkermansia after adrenocorticotropic hormone therapy in patients with West syndrome

BMC Microbiology

Table 1 Characteristics of patients with West Syndrome (WS)

Patient NO.	Etiology	Feeding patterns	Anti-seizure drugs	Clinical outcome	EEG(hypsarrhythmia) after treantment	Fecal sampling time point(the day of ACTH treatment)
1	TSC	AF	None	Spasm-free	Relieved	14
2	Unknown	BF	LEV、TPM、CZP	No response	Persisted	14
3	Unknown	AF + CF	VPA、TPM	Spasm-free	Resolved	15
4	Unknown	AF + CF	None	Relieved	Persisted	14
5	Unknown	CF	None	Relieved	Relieved	15
6	HIE	AF + CF	None	Spasm-free	Persisted	14
7	TSC	CF	None	Relieved	Relieved	14
8	Unknown	BF + CF	TPM、NZP	Relieved	Relieved	14
9	Unknown	BF + CF	VPA、NZP	Spasm-free	Relieved	9
10	HIE	AF	VPA	Relieved	–	14
11	Unknown	BF + CF	None	Relieved	Relieved	15
12	Unknown	MF	VPA、TPM	Relieved	Relieved	14
13	NF1	AF + CF	VPA、TPM、LEV	Spasm-free	Resolved	10
14	FCD	MF	None	Spasm-free	Persisted	14
15	Unknown	BF	VPA、OXC、LEV	Relieved	Relieved	14
16	Unknown	MF	None	Spasm-free	Relieved	14
17	Unknown	CF + MF	None	Spasm-free	Relieved	14
18	Unknown	MF	None	Spasm-free	Relieved	15
19	CCM	AF	VPA	Spasm-free	Relieved	8
20	Unknown	BF	None	Spasm-free	Relieved	14
21	Unknown	MF	TPM	Spasm-free	Resolved	14
22	Unknown	MF	None	Relieved	Persisted	14
23	Unknown	MF	None	Relieved	Persisted	14
24	HIE	AF	None	No response	Relieved	14
25	Unknown	MF	TPM	Spasm-free	Resolved	14
26	TSC	AF	TPM	Spasm-free	Relieved	14
27	Unknown	BF + CF	None	Relieved	Persisted	14
28	Unknown	AF	None	Spasm-free	Relieved	14
29	Unknown	AF	None	Relieved	Relieved	14

AF artificial feeding, BF breast feeding, CF complementary feeding, CCM congenital cleft malformation, CZP clonazepam, EEG electroencephalograph, F female, FCD focal cortical dsysplasia, HIE Hypoxic-ischemic encephalopathy, LEV levetiracetam;M,male, MF mixed feedin, NF1 Neurofibromatosis 1, NZP nitrazepam, OXC oxcarbazepine, TPM topiramate, TSC Tuberous sclerosis, VPA valproic acid. All patients had hypsarrhythmia on electroencephalography

ISSN: 1471-2180