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Table 3 The prediction of SARS-COV-2 N protein phosphorylation site single amino acid variant

From: Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

Sites Kinases Substitution Deletion Insertion Replacements
Variant score Prediction Variant score Prediction Variant score Prediction Variant score Prediction
49 T CDC2 T49A −0.798 Na T49del −1.499 N T49_A50insVA −1.795 N T49_A50delinsVA −0.938 N
57 T PKC,CKI T57A − 1.479 N T57del −3.366 D T57_Q58insVA −0.768 N T57_Q58delinsVA −1.973 N
87Y EGFR Y87A −4.899 D Y87del −3.899 D Y87_R88insVA −4.820 D Y87_R88delinsVA −5.600 D
115 T PKC,CKII T115A −4.678 D T115del −14.005 D T115_G116insVA −10.362 D T115_G116delinsVA −10.295 D
176S CDC2 S176A −1.956 N S176del −1.373 N S176_R177insVA −0.436 N S176_R177delinsVA −4.134 D
232S PKC,CDC2 S232A −0.372 N S232del −1.402 N S232_K233insVA −2.151 N S232_K233delinsVA −0.595 N
245 T PKC T245A −0.005 N T245del −1.055 N T245_V246insVA −2.157 N T245_V246delinsVA −2.021 N
255S PKC S255A 0.397 N S255del −2.807 D S255_K256insVA −2.195 N S255_K256delinsVA −2.067 N
263 T PKG T263A −2.227 N T263del −8.631 D T263_A264insVA −6.701 D T263_A264delinsVA −0.967 N
265 T PKA T265A −0.866 N T265del −6.947 D T265_K266insVA −6.914 D T265_K266delinsVA −4.805 D
271 T DNAPK T271A −2.049 N T271del −9.555 D T271_Q272insVA −7.831 D T271_Q272delinsVA −4.574 D
332 T CKI T332A −1.844 N T332del −6.020 D T332_Y333insVA −1.285 N T332_Y333delinsVA −8.550 D
366 T PKC T366A −0.363 N T366del −0.649 N T366_E367insVA −2.147 N T366_E367delinsVA −2.494 N
379 T DNAPK T379A 0.352 N T379del −0.572 N T379_Q380insVA −0.004 N T379_Q380delinsVA −0.160 N
391 T PKA T391A 0.231 N T391del −0.123 N T391_V392insVA −0.163 N T391_V392delinsVA 0.414 N
393 T CDC2 T393A −0.755 N T393del −0.356 N T393_L394insVA −0.188 N T393_L394delinsVA 0.632 N
413S CDC2 S413A 0.470 N S413del 1.119 N S413_A414insVA 0.998 N S413_A414delinsVA 0.625 N
417 T DNAPK,ATM T417A −0.210 N T417del −0.226 N T417_Q418insVA 0.433 N T417_Q418delinsVA −0.212 N
  1. aDefault threshold is − 2.5, that is: Variants with a score equal to or below − 2.5 are considered “Deleterious”; Variants with a score above − 2.5 are considered “Neutral”