Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

Gao, Tianyi; Gao, Yingdong; Liu, Xiangxiang; Nie, Zhenlin; Sun, Huilin; Lin, Kang; Peng, Hongxin; Wang, Shukui

doi:10.1186/s12866-021-02107-3

BMC Microbiology

Table 3 The prediction of SARS-COV-2 N protein phosphorylation site single amino acid variant

From: Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

Sites	Kinases	Substitution			Deletion			Insertion			Replacements
Sites	Kinases	Variant	score	Prediction	Variant	score	Prediction	Variant	score	Prediction	Variant	score	Prediction
49 T	CDC2	T49A	−0.798	N^a	T49del	−1.499	N	T49_A50insVA	−1.795	N	T49_A50delinsVA	−0.938	N
57 T	PKC,CKI	T57A	− 1.479	N	T57del	−3.366	D	T57_Q58insVA	−0.768	N	T57_Q58delinsVA	−1.973	N
87Y	EGFR	Y87A	−4.899	D	Y87del	−3.899	D	Y87_R88insVA	−4.820	D	Y87_R88delinsVA	−5.600	D
115 T	PKC,CKII	T115A	−4.678	D	T115del	−14.005	D	T115_G116insVA	−10.362	D	T115_G116delinsVA	−10.295	D
176S	CDC2	S176A	−1.956	N	S176del	−1.373	N	S176_R177insVA	−0.436	N	S176_R177delinsVA	−4.134	D
232S	PKC,CDC2	S232A	−0.372	N	S232del	−1.402	N	S232_K233insVA	−2.151	N	S232_K233delinsVA	−0.595	N
245 T	PKC	T245A	−0.005	N	T245del	−1.055	N	T245_V246insVA	−2.157	N	T245_V246delinsVA	−2.021	N
255S	PKC	S255A	0.397	N	S255del	−2.807	D	S255_K256insVA	−2.195	N	S255_K256delinsVA	−2.067	N
263 T	PKG	T263A	−2.227	N	T263del	−8.631	D	T263_A264insVA	−6.701	D	T263_A264delinsVA	−0.967	N
265 T	PKA	T265A	−0.866	N	T265del	−6.947	D	T265_K266insVA	−6.914	D	T265_K266delinsVA	−4.805	D
271 T	DNAPK	T271A	−2.049	N	T271del	−9.555	D	T271_Q272insVA	−7.831	D	T271_Q272delinsVA	−4.574	D
332 T	CKI	T332A	−1.844	N	T332del	−6.020	D	T332_Y333insVA	−1.285	N	T332_Y333delinsVA	−8.550	D
366 T	PKC	T366A	−0.363	N	T366del	−0.649	N	T366_E367insVA	−2.147	N	T366_E367delinsVA	−2.494	N
379 T	DNAPK	T379A	0.352	N	T379del	−0.572	N	T379_Q380insVA	−0.004	N	T379_Q380delinsVA	−0.160	N
391 T	PKA	T391A	0.231	N	T391del	−0.123	N	T391_V392insVA	−0.163	N	T391_V392delinsVA	0.414	N
393 T	CDC2	T393A	−0.755	N	T393del	−0.356	N	T393_L394insVA	−0.188	N	T393_L394delinsVA	0.632	N
413S	CDC2	S413A	0.470	N	S413del	1.119	N	S413_A414insVA	0.998	N	S413_A414delinsVA	0.625	N
417 T	DNAPK,ATM	T417A	−0.210	N	T417del	−0.226	N	T417_Q418insVA	0.433	N	T417_Q418delinsVA	−0.212	N

^aDefault threshold is − 2.5, that is: Variants with a score equal to or below − 2.5 are considered “Deleterious”; Variants with a score above − 2.5 are considered “Neutral”

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ISSN: 1471-2180

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