Synergistic effects of vorinostat (SAHA) and azoles against Aspergillus species and their biofilms

BMC Microbiology

Table 2 SMIC80 and FICIs of combinations of SAHA with azoles against Aspergillus biofilms

Strain	SMIC₈₀ (μg/ml)				SMIC₈₀			SMIC₈₀
Strain	SAHA	VRC	SAHA/VRC	FICI	ITR	SAHA/ITR	FICI	POC	SAHA/POC	FICI
AF293	≥256	≥256	128/128	0.50	≥256	128/64	0.38	≥256	128/128	0.50
AF102	≥256	≥256	128/128	0.50	≥256	128/128	0.50	≥256	128/256	0.75
AF103	≥256	128	128/32	0.50	≥256	128/256	0.75	≥256	128/256	0.75
AF104	≥256	≥256	64/64	0.25	≥256	64/64	0.25	≥256	128/128	0.50
AF105	≥256	≥256	128/128	0.50	≥256	64/128	0.38	≥256	64/64	0.25
AF106	≥256	≥256	128/128	0.50	≥256	128/128	0.50	≥256	128/128	0.50
AF107	≥256	128	128/64	0.75	≥256	128/128	0.50	≥256	128/128	0.50
AF108	≥256	256	128/128	0.75	≥256	64/64	0.25	256	128/128	0.75
AF109	≥256	256	64/32	0.25	≥256	128/128	0.50	256	128/128	0.75
AF1010	≥256	128	128/64	0.75	≥256	128/128	0.50	≥256	128/128	0.50
AF1011	≥256	128	64/64	0.63	≥256	128/128	0.50	≥256	128/128	0.50
AF1012	≥256	128	64/32	0.38	≥256	128/128	0.50	≥256	128/256	0.75
AFLA1	≥256	≥256	128/128	0.50	≥256	128/128	0.50	256	128/128	0.75
AFLA2	≥256	≥256	128/128	0.50	≥256	128/128	0.50	≥256	128/128	0.50
AFLA3	≥256	≥256	128/128	0.50	≥256	128/128	0.50	≥256	64/64	0.25
AFLA4	≥256	≥256	128/64	0.38	≥256	128/128	0.50	≥256	128/128	0.50
AFLA5	≥256	≥256	128/128	0.50	≥256	128/256	0.75	≥256	128/128	0.50
AT101	≥256	128	128/128	1.25	≥256	128/256	0.75	≥256	128/128	0.50
AT102	≥256	128	64/64	0.63	≥256	128/256	0.75	≥256	128/256	0.75
AT103	≥256	≥256	64/64	0.25	≥256	128/128	0.50	≥256	128/128	0.50

FICI results: synergy (FICI of ≤0.5); indifference (no interaction [FICI of > 0.5 to ≤4]). ITR itraconazole, VRC voriconazole, POC posaconazole, SAHA suberoylanilide hydroxamic acid

ISSN: 1471-2180