Table 6 Hematology of male and female (mice) treated orally with P. acidilactici J9 for 14 days
From: Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model
Sex | Parameters | Dose (mg) | ||||
|---|---|---|---|---|---|---|
Control | 500 | 1000 | 2000 | |||
Male | CBC | WBC (×103/μL) | 2.672 ± 0.65 | 2.066 ± 0.63 | 2.016 ± 1.01 | 2.474 ± 0.96 |
RBC (×106/μL) | 9.88 ± 0.33 | 9.518 ± 0.26 | 10.00 ± 0.14 | 9.876 ± 0.32 | ||
HGB (g/dL) | 15.14 ± 0.64 | 14.72 ± 0.36 | 15.36 ± 0.28 | 15.26 ± 0.53 | ||
HCT (%) | 51.62 ± 2.24 | 49.42 ± 1.43 | 51.38 ± 1.17 | 50.90 ± 2.09 | ||
MCV (fL) | 52.26 ± 0.69 | 51.9 ± 0.42 | 51.36 ± 1.09 | 51.54 ± 0.72 | ||
MCH (pg) | 15.32 ± 0.22 | 15.46 ± 0.21 | 15.34 ± 0.22 | 15.46 ± 0.23 | ||
MCHC (g/dL) | 29.30 ± 0.23 | 29.78 ± 0.29 | 29.88 ± 0.43 | 29.96 ± 0.40 | ||
CHCM (g/dL) | 28.16 ± 0.35 | 28.16 ± 0.11 | 28.64 ± 0.44 | 28.68 ± 0.45 | ||
RDW (%) | 13.36 ± 0.38 | 13.88 ± 0.40 | 13.30 ± 0.50 | 13.26 ± 0.94 | ||
HDW (g/dL) | 1.45 ± 0.02 | 1.45 ± 0.06 | 1.45 ± 0.04 | 1.45 ± 0.03 | ||
CH (pg) | 14.68 ± 0.19 | 14.58 ± 0.08 | 14.66 ± 0.17 | 14.74 ± 0.09 | ||
CHDW (%) | 2.00 ± 0.05 | 2.07 ± 0.08 | 2.00 ± 0.05 | 2.01 ± 0.11 | ||
PLT (×103/μL) | 1263.20 ± 73.52 | 1244.80 ± 57.87 | 1238.60 ± 61.75 | 1202.00 ± 60.76 | ||
MPV (fL) | 7.44 ± 0.17 | 7.88 ± 0.05 | 7.52 ± 0.08 | 7.48 ± 0.26 | ||
PDW (%) | 60.38 ± 1.85 | 57.30 ± 1.62 | 55.80 ± 1.62 | 55.96 ± 2.34 | ||
PCT (%) | 0.94 ± 0.06 | 0.98 ± 0.05 | 0.93 ± 0.05 | 0.90 ± 0.06 | ||
DIFF | NEUT (×103/μL) | 0.34 ± 0.13 | 0.18 ± 0.05 | 0.19 ± 0.09 | 0.21 ± 0.05 | |
NEUT (%) | 12.5 ± 3.19 | 9.26 ± 2.15 | 9.56 ± 1.06 | 8.94 ± 1.50 | ||
LYMPH (×103/μL) | 2.25 ± 0.52 | 1.83 ± 0.56 | 1.78 ± 0.89 | 2.22 ± 0.89 | ||
LYMPH (%) | 84.46 ± 3.46 | 88.48 ± 2.27 | 88.52 ± 1.21 | 89.46 ± 1.17 | ||
MONO (×103/μL) | 0.02 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | ||
MONO (%) | 0.54 ± 0.34 | 0.32 ± 0.28 | 0.28 ± 0.18 | 0.32 ± 0.16 | ||
EOS (×103/μL) | 0.05 ± 0.02 | 0.03 ± 0.04 | 0.02 ± 0.01 | 0.01 ± 0.01 | ||
EOS (%) | 1.64 ± 0.50 | 1.30 ± 1.31 | 0.76 ± 0.30 | 0.48 ± 0.21 | ||
BASO (×103/μL) | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | ||
BASO (%) | 0.28 ± 0.13 | 0.40 ± 0.20 | 0.34 ± 0.24 | 0.26 ± 0.19 | ||
LUC (×103/μL) | 0.02 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.02 ± 0.01 | ||
LUC (%) | 0.62 ± 0.16 | 0.24 ± 0.27 | 0.48 ± 0.33 | 0.56 ± 0.23 | ||
RETI | Reticulocyte (×109/μL) | 301.60 ± 47.96 | 258.32 ± 30.72 | 302.89 ± 10.26 | 298.02 ± 63.69 | |
Reticulocyte (%) | 3.15 ± 0.51 | 2.71 ± 0.25 | 3.03 ± 0.12 | 3.00 ± 0.56 | ||
MCVr (fL) | 58.00 ± 0.51 | 57.46 ± 0.48 | 57.60 ± 0.65 | 57.86 ± 1.13 | ||
CHCMr (g/dL) | 26.24 ± 0.17 | 25.92 ± 0.13 | 26.30 ± 0.19 | 26.18 ± 0.31 | ||
RDWr (%) | 12.06 ± 0.65 | 12.36 ± 0.66 | 11.96 ± 0.64 | 12.20 ± 0.85 | ||
HDWr (%) | 2.34 ± 0.12 | 2.40 ± 0.10 | 2.43 ± 0.07 | 2.52 ± 0.10 | ||
CHr (pg) | 15.20 ± 0.25 | 14.86 ± 0.22 | 15.12 ± 0.11 | 15.12 ± 0.16 | ||
CHDWr (%) | 1.98 ± 0.08 | 1.97 ± 0.07 | 1.92 ± 0.05 | 1.97 ± 0.06 | ||
Female | CBC | WBC (×103/μL) | 2.95 ± 0.60 | 2.53 ± 1.08 | 2.75 ± 0.70 | 3.32 ± 1.34 |
RBC (×106/μL) | 9.51 ± 0.13 | 10.19 ± 0.15 | 10.07 ± 0.22 | 9.97 ± 0.31 | ||
HGB (g/dL) | 14.72 ± 0.21 | 15.80 ± 0.47 | 15.60 ± 0.26 | 15.74 ± 0.31 | ||
HCT (%) | 49.12 ± 0.73 | 52.20 ± 1.70 | 51.48 ± 1.52 | 50.44 ± 1.77 | ||
MCV (fL) | 51.64 ± 0.43 | 51.16 ± 1.04 | 51.12 ± 0.79 | 50.60 ± 0.62 | ||
MCH (pg) | 15.50 ± 0.23 | 15.48 ± 0.33 | 15.50 ± 0.33 | 15.78 ± 0.42 | ||
MCHC (g/dL) | 29.98 ± 0.36 | 30.28 ± 0.35 | 30.32 ± 0.61 | 31.20 ± 0.91 | ||
CHCM (g/dL) | 28.74 ± 0.34 | 28.94 ± 0.40 | 28.96 ± 0.43 | 29.5 ± 0.35 | ||
RDW (%) | 13.68 ± 0.46 | 13.90 ± 0.46 | 13.00 ± 0.52 | 13.02 ± 0.46 | ||
HDW (g/dL) | 1.50 ± 0.05 | 1.54 ± 0.03 | 1.52 ± 0.04 | 1.59 ± 0.02 | ||
CH (pg) | 14.76 ± 0.13 | 14.74 ± 0.21 | 14.76 ± 0.15 | 14.86 ± 0.06 | ||
CHDW (%) | 2.07 ± 0.06 | 2.11 ± 0.05 | 2.00 ± 0.08 | 2.03 ± 0.06 | ||
PLT (×103/μL) | 955.60 ± 64.27 | 1102.40 ± 63.27 | 1129.80 ± 94.82 | 1035.00 ± 107.62 | ||
MPV (fL) | 7.56 ± 0.35 | 7.70 ± 0.16 | 7.82 ± 0.11 | 7.38 ± 0.47 | ||
PDW (%) | 57.78 ± 3.04 | 57.10 ± 2.82 | 54.94 ± 1.31 | 57.68 ± 3.19 | ||
PCT (%) | 0.73 ± 0.07 | 0.85 ± 0.06 | 0.89 ± 0.08 | 0.77 ± 0.11 | ||
DIFF | NEUT (×103/μL) | 0.28 ± 0.07 | 0.29 ± 0.06 | 0.25 ± 0.08 | 0.23 ± 0.12 | |
NEUT (%) | 9.48 ± 0.42 | 12.38 ± 2.50 | 9.70 ± 3.01 | 6.94 ± 1.34 | ||
LYMPH (×103/μL) | 2.61 ± 0.53 | 2.20 ± 1.01 | 2.45 ± 0.72 | 3.03 ± 1.19 | ||
LYMPH (%) | 88.50 ± 0.39 | 86.24 ± 2.40 | 88.74 ± 3.30 | 91.42 ± 1.61 | ||
MONO (×103/μL) | 0.01 ± 0.00 | 0.00 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.00 | ||
MONO (%) | 0.46 ± 0.15 | 0.20 ± 0.12 | 0.22 ± 0.13 | 0.22 ± 0.08 | ||
EOS (×103/μL) | 0.02 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | ||
EOS (%) | 0.80 ± 0.25 | 0.34 ± 0.38 | 0.34 ± 0.26 | 0.42 ± 0.29 | ||
BASO (×103/μL) | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.00 | 0.01 ± 0.01 | ||
BASO (%) | 0.32 ± 0.22 | 0.30 ± 0.12 | 0.38 ± 0.19 | 0.30 ± 0.19 | ||
LUC (×103/μL) | 0.01 ± 0.01 | 0.02 ± 0.01 | 0.02 ± 0.01 | 0.03 ± 0.02 | ||
LUC (%) | 0.48 ± 0.13 | 0.54 ± 0.18 | 0.64 ± 0.51 | 0.66 ± 0.38 | ||
RETI | Reticulocyte (×109/μL) | 309.34 ± 52.93 | 304.60 ± 43.32 | 277.50 ± 38.28 | 351.10 ± 49.29 | |
Reticulocyte (%) | 3.25 ± 0.53 | 2.99 ± 0.42 | 2.76 ± 0.41 | 3.53 ± 0.60 | ||
MCVr (fL) | 57.90 ± 0.50 | 57.86 ± 1.25 | 57.36 ± 0.70 | 58.12 ± 0.75 | ||
CHCMr (g/dL) | 26.46 ± 0.18 | 26.42 ± 0.33 | 26.44 ± 0.11 | 26.76 ± 0.23 | ||
RDWr (%) | 13.08 ± 0.93 | 12.14 ± 1.01 | 13.40 ± 0.70 | 13.22 ± 1.00 | ||
HDWr (%) | 2.58 ± 0.11 | 2.63 ± 0.11 | 2.75 ± 0.12 | 2.81 ± 0.12 | ||
CHr (pg) | 15.30 ± 0.23 | 15.24 ± 0.42 | 15.12 ± 0.22 | 15.52 ± 0.13 | ||
CHDWr (%) | 2.03 ± 0.04 | 2.01 ± 0.08 | 2.07 ± 0.07 | 2.13 ± 0.10 | ||