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Table 6 Hematology of male and female (mice) treated orally with P. acidilactici J9 for 14 days

From: Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model

Sex Parameters Dose (mg)
Control 500 1000 2000
Male CBC WBC (×103/μL) 2.672 ± 0.65 2.066 ± 0.63 2.016 ± 1.01 2.474 ± 0.96
RBC (×106/μL) 9.88 ± 0.33 9.518 ± 0.26 10.00 ± 0.14 9.876 ± 0.32
HGB (g/dL) 15.14 ± 0.64 14.72 ± 0.36 15.36 ± 0.28 15.26 ± 0.53
HCT (%) 51.62 ± 2.24 49.42 ± 1.43 51.38 ± 1.17 50.90 ± 2.09
MCV (fL) 52.26 ± 0.69 51.9 ± 0.42 51.36 ± 1.09 51.54 ± 0.72
MCH (pg) 15.32 ± 0.22 15.46 ± 0.21 15.34 ± 0.22 15.46 ± 0.23
MCHC (g/dL) 29.30 ± 0.23 29.78 ± 0.29 29.88 ± 0.43 29.96 ± 0.40
CHCM (g/dL) 28.16 ± 0.35 28.16 ± 0.11 28.64 ± 0.44 28.68 ± 0.45
RDW (%) 13.36 ± 0.38 13.88 ± 0.40 13.30 ± 0.50 13.26 ± 0.94
HDW (g/dL) 1.45 ± 0.02 1.45 ± 0.06 1.45 ± 0.04 1.45 ± 0.03
CH (pg) 14.68 ± 0.19 14.58 ± 0.08 14.66 ± 0.17 14.74 ± 0.09
CHDW (%) 2.00 ± 0.05 2.07 ± 0.08 2.00 ± 0.05 2.01 ± 0.11
PLT (×103/μL) 1263.20 ± 73.52 1244.80 ± 57.87 1238.60 ± 61.75 1202.00 ± 60.76
MPV (fL) 7.44 ± 0.17 7.88 ± 0.05 7.52 ± 0.08 7.48 ± 0.26
PDW (%) 60.38 ± 1.85 57.30 ± 1.62 55.80 ± 1.62 55.96 ± 2.34
PCT (%) 0.94 ± 0.06 0.98 ± 0.05 0.93 ± 0.05 0.90 ± 0.06
DIFF NEUT (×103/μL) 0.34 ± 0.13 0.18 ± 0.05 0.19 ± 0.09 0.21 ± 0.05
NEUT (%) 12.5 ± 3.19 9.26 ± 2.15 9.56 ± 1.06 8.94 ± 1.50
LYMPH (×103/μL) 2.25 ± 0.52 1.83 ± 0.56 1.78 ± 0.89 2.22 ± 0.89
LYMPH (%) 84.46 ± 3.46 88.48 ± 2.27 88.52 ± 1.21 89.46 ± 1.17
MONO (×103/μL) 0.02 ± 0.01 0.01 ± 0.01 0.01 ± 0.01 0.01 ± 0.01
MONO (%) 0.54 ± 0.34 0.32 ± 0.28 0.28 ± 0.18 0.32 ± 0.16
EOS (×103/μL) 0.05 ± 0.02 0.03 ± 0.04 0.02 ± 0.01 0.01 ± 0.01
EOS (%) 1.64 ± 0.50 1.30 ± 1.31 0.76 ± 0.30 0.48 ± 0.21
BASO (×103/μL) 0.01 ± 0.01 0.01 ± 0.01 0.01 ± 0.01 0.01 ± 0.01
BASO (%) 0.28 ± 0.13 0.40 ± 0.20 0.34 ± 0.24 0.26 ± 0.19
LUC (×103/μL) 0.02 ± 0.01 0.01 ± 0.01 0.01 ± 0.01 0.02 ± 0.01
LUC (%) 0.62 ± 0.16 0.24 ± 0.27 0.48 ± 0.33 0.56 ± 0.23
RETI Reticulocyte (×109/μL) 301.60 ± 47.96 258.32 ± 30.72 302.89 ± 10.26 298.02 ± 63.69
Reticulocyte (%) 3.15 ± 0.51 2.71 ± 0.25 3.03 ± 0.12 3.00 ± 0.56
MCVr (fL) 58.00 ± 0.51 57.46 ± 0.48 57.60 ± 0.65 57.86 ± 1.13
CHCMr (g/dL) 26.24 ± 0.17 25.92 ± 0.13 26.30 ± 0.19 26.18 ± 0.31
RDWr (%) 12.06 ± 0.65 12.36 ± 0.66 11.96 ± 0.64 12.20 ± 0.85
HDWr (%) 2.34 ± 0.12 2.40 ± 0.10 2.43 ± 0.07 2.52 ± 0.10
CHr (pg) 15.20 ± 0.25 14.86 ± 0.22 15.12 ± 0.11 15.12 ± 0.16
CHDWr (%) 1.98 ± 0.08 1.97 ± 0.07 1.92 ± 0.05 1.97 ± 0.06
Female CBC WBC (×103/μL) 2.95 ± 0.60 2.53 ± 1.08 2.75 ± 0.70 3.32 ± 1.34
RBC (×106/μL) 9.51 ± 0.13 10.19 ± 0.15 10.07 ± 0.22 9.97 ± 0.31
HGB (g/dL) 14.72 ± 0.21 15.80 ± 0.47 15.60 ± 0.26 15.74 ± 0.31
HCT (%) 49.12 ± 0.73 52.20 ± 1.70 51.48 ± 1.52 50.44 ± 1.77
MCV (fL) 51.64 ± 0.43 51.16 ± 1.04 51.12 ± 0.79 50.60 ± 0.62
MCH (pg) 15.50 ± 0.23 15.48 ± 0.33 15.50 ± 0.33 15.78 ± 0.42
MCHC (g/dL) 29.98 ± 0.36 30.28 ± 0.35 30.32 ± 0.61 31.20 ± 0.91
CHCM (g/dL) 28.74 ± 0.34 28.94 ± 0.40 28.96 ± 0.43 29.5 ± 0.35
RDW (%) 13.68 ± 0.46 13.90 ± 0.46 13.00 ± 0.52 13.02 ± 0.46
HDW (g/dL) 1.50 ± 0.05 1.54 ± 0.03 1.52 ± 0.04 1.59 ± 0.02
CH (pg) 14.76 ± 0.13 14.74 ± 0.21 14.76 ± 0.15 14.86 ± 0.06
CHDW (%) 2.07 ± 0.06 2.11 ± 0.05 2.00 ± 0.08 2.03 ± 0.06
PLT (×103/μL) 955.60 ± 64.27 1102.40 ± 63.27 1129.80 ± 94.82 1035.00 ± 107.62
MPV (fL) 7.56 ± 0.35 7.70 ± 0.16 7.82 ± 0.11 7.38 ± 0.47
PDW (%) 57.78 ± 3.04 57.10 ± 2.82 54.94 ± 1.31 57.68 ± 3.19
PCT (%) 0.73 ± 0.07 0.85 ± 0.06 0.89 ± 0.08 0.77 ± 0.11
DIFF NEUT (×103/μL) 0.28 ± 0.07 0.29 ± 0.06 0.25 ± 0.08 0.23 ± 0.12
NEUT (%) 9.48 ± 0.42 12.38 ± 2.50 9.70 ± 3.01 6.94 ± 1.34
LYMPH (×103/μL) 2.61 ± 0.53 2.20 ± 1.01 2.45 ± 0.72 3.03 ± 1.19
LYMPH (%) 88.50 ± 0.39 86.24 ± 2.40 88.74 ± 3.30 91.42 ± 1.61
MONO (×103/μL) 0.01 ± 0.00 0.00 ± 0.01 0.01 ± 0.01 0.01 ± 0.00
MONO (%) 0.46 ± 0.15 0.20 ± 0.12 0.22 ± 0.13 0.22 ± 0.08
EOS (×103/μL) 0.02 ± 0.01 0.01 ± 0.01 0.01 ± 0.01 0.01 ± 0.01
EOS (%) 0.80 ± 0.25 0.34 ± 0.38 0.34 ± 0.26 0.42 ± 0.29
BASO (×103/μL) 0.01 ± 0.01 0.01 ± 0.01 0.01 ± 0.00 0.01 ± 0.01
BASO (%) 0.32 ± 0.22 0.30 ± 0.12 0.38 ± 0.19 0.30 ± 0.19
LUC (×103/μL) 0.01 ± 0.01 0.02 ± 0.01 0.02 ± 0.01 0.03 ± 0.02
LUC (%) 0.48 ± 0.13 0.54 ± 0.18 0.64 ± 0.51 0.66 ± 0.38
RETI Reticulocyte (×109/μL) 309.34 ± 52.93 304.60 ± 43.32 277.50 ± 38.28 351.10 ± 49.29
Reticulocyte (%) 3.25 ± 0.53 2.99 ± 0.42 2.76 ± 0.41 3.53 ± 0.60
MCVr (fL) 57.90 ± 0.50 57.86 ± 1.25 57.36 ± 0.70 58.12 ± 0.75
CHCMr (g/dL) 26.46 ± 0.18 26.42 ± 0.33 26.44 ± 0.11 26.76 ± 0.23
RDWr (%) 13.08 ± 0.93 12.14 ± 1.01 13.40 ± 0.70 13.22 ± 1.00
HDWr (%) 2.58 ± 0.11 2.63 ± 0.11 2.75 ± 0.12 2.81 ± 0.12
CHr (pg) 15.30 ± 0.23 15.24 ± 0.42 15.12 ± 0.22 15.52 ± 0.13
CHDWr (%) 2.03 ± 0.04 2.01 ± 0.08 2.07 ± 0.07 2.13 ± 0.10
  1. Values are expressed as mean ± SE (n = 5)
  2. NS not significantly different among groups