Fig. 6From: Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cellsProposed model of ILA activation. ILA activates AhR which increases expression of AhR regulated gene CYP1A1 as well as increasing activity of Nrf2. Activated Nrf2 leads to increased expression of cytoprotective genes to reduce oxidative cellular stress brought about by inflammatory agents such as LPS or TNF-αBack to article page