Fig. 1

Shared OTU across the non-puberty and puberty groups. Different colors represent different groups, the interior of each circle represents the number of observed OTUs in the certain group. The overlapping area or intersection represents the set of OTU commonly present in the counterpart groups. Likewise, the single-layer zone represents the number of OTUs uniquely found in the certain group. C1: puberty group; C2: non-puberty group