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Table 2 Determination of Erava MIC value in the S. aureus derivatives with the overexpression of the three candidate genes and tet(K) and their impact on PAPs

From: Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus

Vectors Strains Erava MIC (mg/L) PAP
Parental isolates Derivative isolatesa
pRS00550 SE7 0.25 0.125 +
CHS545 0.125 0.125 +
CHS569 0.125 0.125 +
pRS01625 SE4 0.125 0.125 +
SE7 0.125 0.125 +
SE13 0.125 0.125 +
CHS545 0.125 0.125 +
CHS569 0.0625 0.125 +
pRS03535 SE13 0.125 0.125
CHS545 0.125 0.125
ptetK SE7 0.125 0.125
SE13 0.125 0.0625
CHS545 0.25 0.125
CHS569 0.125 0.125
  1. PAP population analysis profiling
  2. a: The overexpression of USA300HOU_RS03535, USA300HOU_ RS01625, USA300HOU_RS00550 and tet(K) in S. aureus clinical isolates SE4, SE7, SE13, CHS545 and CHS569