Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus

Table 2 Determination of Erava MIC value in the S. aureus derivatives with the overexpression of the three candidate genes and tet(K) and their impact on PAPs

Vectors	Strains	Erava MIC (mg/L)		PAP
Vectors	Strains	Parental isolates	Derivative isolates^a	PAP
pRS00550	SE7	0.25	0.125	+
	CHS545	0.125	0.125	+
	CHS569	0.125	0.125	+
pRS01625	SE4	0.125	0.125	+
	SE7	0.125	0.125	+
	SE13	0.125	0.125	+
	CHS545	0.125	0.125	+
	CHS569	0.0625	0.125	+
pRS03535	SE13	0.125	0.125	–
pRS03535	CHS545	0.125	0.125	–
ptetK	SE7	0.125	0.125	–
	SE13	0.125	0.0625	–
	CHS545	0.25	0.125	–
	CHS569	0.125	0.125	–

PAP population analysis profiling
^a: The overexpression of USA300HOU_RS03535, USA300HOU_ RS01625, USA300HOU_RS00550 and tet(K) in S. aureus clinical isolates SE4, SE7, SE13, CHS545 and CHS569

ISSN: 1471-2180