Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

Tong Liu; Xiang Gu; Li-Xiang Li; Ming Li; Bing Li; Xiao Cui; Xiu-li Zuo

doi:10.1186/s12866-020-01841-4

Table 2 Associations between clinical characteristics and differential urinary metabolites in IBS-D patients

From: Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

KEGG ID	Metabolite Name	Related Parameter	Spearman’s Coefficient	P value
C05576	3_4-Dihydroxyphenylethyleneglycol	IBS-SSS^a	0.216	0.026
C02722	n-Hexanamide	IBS-SSS	0.208	0.032
C01546	2-Furoate	IBS-SSS	0.424	0.000
C16505	(10S)-Juvenile hormone III diol	IBS-SSS	0.366	0.000
C16674	formyl-isoglutamine	IBS-SSS	0.329	0.001
C01262	Anserine	IBS-SSS	- 0.296	0.002
C01152	1-Methylhistidine	IBS-SSS	- 0.260	0.007
C03652	(2R_3S)-2_3-Dimethylmalate	IBS-SSS	0.250	0.009
C16365	5-Acetylamino-6-formylamino-3-methyluracil	IBS-SSS	- 0.236	0.014
C19891	1D-chiro-inositol	IBS-SSS	- 0.230	0.017
C00122	Fumaricacid	IBS-SSS	- 0.218	0.024
C00451	(1R_2S)-1-Hydroxypropane-1_2_3-tricarboxylate	IBS-SSS	0.196	0.043
C03210	2_2’-Iminodipropanoate	IBS-SSS	0.192	0.047
C16358	1-Methylxanthine	SAS^b	- 0.286	0.019
C05577	3_4-Dihydroxymandelaldehyde	SAS	- 0.383	0.001
C05596	4-Hydroxyphenylacetylglycine	SAS	- 0.337	0.005
C19891	1D-chiro-inositol	SAS	- 0.336	0.005
C16674	formyl-isoglutamine	SAS	- 0.306	0.012
C04349	(4S)-4_6-Dihydroxy-2_5-dioxohexanoate	SAS	- 0.294	0.016
C00122	Fumaricacid	SAS	- 0.292	0.017
C05100	3-Ureidoisobutyrate	SAS	- 0.281	0.021
C01152	1-Methylhistidine	SAS	- 0.263	0.031
C16358	1-Methylxanthine	SDS^c	- 0.347	0.004
C03711	N-Methylphenylethanolamine	SDS	- 0.266	0.030
C02646	4-Coumarylalcohol	SDS	- 0.245	0.046
C03652	(2R_3S)-2_3-Dimethylmalate	SDS	- 0.268	0.028
C05577	3_4-Dihydroxymandelaldehyde	SDS	- 0.267	0.029
C01087	(R)-2-Hydroxyglutarate	SDS	- 0.266	0.030
C01092	8-Amino-7-oxononanoate	SDS	- 0.265	0.030
C01152	1-Methylhistidine	SDS	- 0.250	0.042
C05596	4-Hydroxyphenylacetylglycine	SDS	- 0.242	0.049
C04546	(R)-3-((R)-3-Hydroxybutanoyloxy)butanoate	SDS	- 0.242	0.049
C01262	Anserine	HAM-A^d	- 0.253	0.039

^aIBS-SSS IBS symptom severity scale, ^bSAS Self-reported anxiety scale, ^cSDS Self-reported depression scale, ^dHAM-A Hamilton anxiety scale

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