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Table 2 Associations between clinical characteristics and differential urinary metabolites in IBS-D patients

From: Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

KEGG ID Metabolite Name Related Parameter Spearman’s Coefficient P value
C05576 3_4-Dihydroxyphenylethyleneglycol IBS-SSSa 0.216 0.026
C02722 n-Hexanamide IBS-SSS 0.208 0.032
C01546 2-Furoate IBS-SSS 0.424 0.000
C16505 (10S)-Juvenile hormone III diol IBS-SSS 0.366 0.000
C16674 formyl-isoglutamine IBS-SSS 0.329 0.001
C01262 Anserine IBS-SSS - 0.296 0.002
C01152 1-Methylhistidine IBS-SSS - 0.260 0.007
C03652 (2R_3S)-2_3-Dimethylmalate IBS-SSS 0.250 0.009
C16365 5-Acetylamino-6-formylamino-3-methyluracil IBS-SSS - 0.236 0.014
C19891 1D-chiro-inositol IBS-SSS - 0.230 0.017
C00122 Fumaricacid IBS-SSS - 0.218 0.024
C00451 (1R_2S)-1-Hydroxypropane-1_2_3-tricarboxylate IBS-SSS 0.196 0.043
C03210 2_2’-Iminodipropanoate IBS-SSS 0.192 0.047
C16358 1-Methylxanthine SASb - 0.286 0.019
C05577 3_4-Dihydroxymandelaldehyde SAS - 0.383 0.001
C05596 4-Hydroxyphenylacetylglycine SAS - 0.337 0.005
C19891 1D-chiro-inositol SAS - 0.336 0.005
C16674 formyl-isoglutamine SAS - 0.306 0.012
C04349 (4S)-4_6-Dihydroxy-2_5-dioxohexanoate SAS - 0.294 0.016
C00122 Fumaricacid SAS - 0.292 0.017
C05100 3-Ureidoisobutyrate SAS - 0.281 0.021
C01152 1-Methylhistidine SAS - 0.263 0.031
C16358 1-Methylxanthine SDSc - 0.347 0.004
C03711 N-Methylphenylethanolamine SDS - 0.266 0.030
C02646 4-Coumarylalcohol SDS - 0.245 0.046
C03652 (2R_3S)-2_3-Dimethylmalate SDS - 0.268 0.028
C05577 3_4-Dihydroxymandelaldehyde SDS - 0.267 0.029
C01087 (R)-2-Hydroxyglutarate SDS - 0.266 0.030
C01092 8-Amino-7-oxononanoate SDS - 0.265 0.030
C01152 1-Methylhistidine SDS - 0.250 0.042
C05596 4-Hydroxyphenylacetylglycine SDS - 0.242 0.049
C04546 (R)-3-((R)-3-Hydroxybutanoyloxy)butanoate SDS - 0.242 0.049
C01262 Anserine HAM-Ad - 0.253 0.039
  1. aIBS-SSS IBS symptom severity scale, bSAS Self-reported anxiety scale, cSDS Self-reported depression scale, dHAM-A Hamilton anxiety scale