Table 2 Associations between clinical characteristics and differential urinary metabolites in IBS-D patients
KEGG ID | Metabolite Name | Related Parameter | Spearman’s Coefficient | P value |
|---|---|---|---|---|
C05576 | 3_4-Dihydroxyphenylethyleneglycol | IBS-SSSa | 0.216 | 0.026 |
C02722 | n-Hexanamide | IBS-SSS | 0.208 | 0.032 |
C01546 | 2-Furoate | IBS-SSS | 0.424 | 0.000 |
C16505 | (10S)-Juvenile hormone III diol | IBS-SSS | 0.366 | 0.000 |
C16674 | formyl-isoglutamine | IBS-SSS | 0.329 | 0.001 |
C01262 | Anserine | IBS-SSS | - 0.296 | 0.002 |
C01152 | 1-Methylhistidine | IBS-SSS | - 0.260 | 0.007 |
C03652 | (2R_3S)-2_3-Dimethylmalate | IBS-SSS | 0.250 | 0.009 |
C16365 | 5-Acetylamino-6-formylamino-3-methyluracil | IBS-SSS | - 0.236 | 0.014 |
C19891 | 1D-chiro-inositol | IBS-SSS | - 0.230 | 0.017 |
C00122 | Fumaricacid | IBS-SSS | - 0.218 | 0.024 |
C00451 | (1R_2S)-1-Hydroxypropane-1_2_3-tricarboxylate | IBS-SSS | 0.196 | 0.043 |
C03210 | 2_2’-Iminodipropanoate | IBS-SSS | 0.192 | 0.047 |
C16358 | 1-Methylxanthine | SASb | - 0.286 | 0.019 |
C05577 | 3_4-Dihydroxymandelaldehyde | SAS | - 0.383 | 0.001 |
C05596 | 4-Hydroxyphenylacetylglycine | SAS | - 0.337 | 0.005 |
C19891 | 1D-chiro-inositol | SAS | - 0.336 | 0.005 |
C16674 | formyl-isoglutamine | SAS | - 0.306 | 0.012 |
C04349 | (4S)-4_6-Dihydroxy-2_5-dioxohexanoate | SAS | - 0.294 | 0.016 |
C00122 | Fumaricacid | SAS | - 0.292 | 0.017 |
C05100 | 3-Ureidoisobutyrate | SAS | - 0.281 | 0.021 |
C01152 | 1-Methylhistidine | SAS | - 0.263 | 0.031 |
C16358 | 1-Methylxanthine | SDSc | - 0.347 | 0.004 |
C03711 | N-Methylphenylethanolamine | SDS | - 0.266 | 0.030 |
C02646 | 4-Coumarylalcohol | SDS | - 0.245 | 0.046 |
C03652 | (2R_3S)-2_3-Dimethylmalate | SDS | - 0.268 | 0.028 |
C05577 | 3_4-Dihydroxymandelaldehyde | SDS | - 0.267 | 0.029 |
C01087 | (R)-2-Hydroxyglutarate | SDS | - 0.266 | 0.030 |
C01092 | 8-Amino-7-oxononanoate | SDS | - 0.265 | 0.030 |
C01152 | 1-Methylhistidine | SDS | - 0.250 | 0.042 |
C05596 | 4-Hydroxyphenylacetylglycine | SDS | - 0.242 | 0.049 |
C04546 | (R)-3-((R)-3-Hydroxybutanoyloxy)butanoate | SDS | - 0.242 | 0.049 |
C01262 | Anserine | HAM-Ad | - 0.253 | 0.039 |