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Table 1 MIC50 and MIC90 of Amphotericin B, Fluconazole and SDF against four different Candida species (as determined by broth microdilution assay)

From: Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species

Candida species (number of isolates) Silver Diamine Fluoride volumes (μl) (containing mg of silver ions)SDF μl (mg of silver ions)Fluconazole (μg)Amphotericin B (μg)
  0.625 μl (0.156)1.25 μl (0.313)2.5 μl (0.625)5 μl (1.25)10 μl (2.5)15 μl (3.75)MIC50 MIC90MIC50 MIC90MIC50 MIC90
C.albicans(10)Number of isolates (percent growth)10 (100%)9 (90%)7 (70%)1 (10%)0 (0%)0 (0%)2.5 (0.625)
5.0 (1.25)
0.25
1.0
0.5
1.0
C.krusei(10)10 (100%)7 (70%)2 (20%)0 (0%)0 (0%)0 (0%)1.25 (0.313)
2.5 (0.625)
16
≥32
0.25
0.5
C.glabrata(5)5 (100%)4 (80%)1 (20%)0 (0%)0 (0%)0 (0%)1.25 (0.313)
2.5 (0.625)
8.0
32
0.25
0.5
C.tropicalis (10)10 (100%)10 (100%)10 (100%)4 (40%)1 (10%)0 (0%)5 (1.25)
10 (2.5)
1.0
2.0
1.0
2.0