Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia

Table 2 Metabolism and enzyme GO terms significantly enriched in S. maltophilia JV3-specific response (VSR) genes

GO category	Term	Count	%	FDR
Biological process	single-organism metabolic process	49	22.68	2.47E-06
	Small molecule metabolic process	27	12.5	5.27E-04
	organic acid metabolic process	22	10.19	1.64E-05
	carboxylic acid metabolic process	21	9.72	2.21E-05
	monocarboxylic acid metabolic process	18	8.33	8.53E-07
	flavonoid glucuronidation	14	6.48	3.02E-09
	flavonoid biosynthetic process	14	6.48	3.02E-09
	oxidation-reduction process	21	9.72	0.0433
	transition metal ion transport	7	3.24	0.0468
Molecular function	catalytic activity	89	41.20	0.00174
	transferase activity, transferring glycosyl groups	17	7.87	0.00203
	transferase activity, transferring hexosyl groups	14	6.48	1.76E-07
	glucuronosyltransferase activity	12	5.56	9.70E-06
	UDP-glycosyltransferase activity	16	7.41	0.00155
	carboxylic ester hydrolase activity	11	5.09	7.24E-04
Cellular component	extracellular region	20	9.26	0.0295

Gene ontology (GO) enrichment analysis was performed on the VSR genes using DAVID Bioinformatics Resources 6.8. Of the 225 VSR genes, 216 were identified in DAVID and considered for analysis. GO analysis identifies terms relating to the biological process, molecular function, or cellular component that are significantly enriched among a list of genes. Indented terms indicate child terms, or subcategories, of the term listed above, with the parent term left-aligned. Note that the degree of indention of each term does not reflect absolute GO term level within each category. Count is the number of genes corresponding to each GO term. Percent is the count/216 total analyzed. FDR is the false discovery rate-corrected EASE enrichment score to account for multiple testing. Only terms with FDR <0.05 and the most descriptive term for each unique gene list are shown

ISSN: 1471-2180