Table 1 Differentially expressed genes in whole blood assay with standard combination treatment that are found in known TB pathways (as reported in Honeyborne et al) [1]
From: Gene expression responses to anti-tuberculous drugs in a whole blood model
Gene pathway | DEGs found in whole blood assay with standard combination treatment | Direction of differential expression |
|---|---|---|
DosR regulon | nrdZ | Up |
KstR regulon | Rv1628c | Up |
Triacylglycerol synthesis | Rv3087 | Up |
Aerobic respiration | cta/C/D/E; nuoD/G/K; qcRA/B/C | Down |
ATP synthesis | atpA/B/C/D/E/F/G | Down |
Citric acid cycle | gltA2; Rv0247c; Rv0248c; sucC | Down |
Fatty acid synthesis | fabD; fabG1; fas; kasA/B | Down |
Mycolic acid biosynthesis | cmaA2; fadD32; mmaA3/A4; pcaA; korA | Down |
Ribosome biosynthesis | rplx11; rpmX5; rpoA/B/C; rpsAx13 | Down |