Fig. 2

Heatmap of gene profiles obtained from cultures with individual anti-TB drugs. The dendrograms are generated by hierarchical clustering using Euclidean distance and complete linkage method. Each column represents a separate whole blood assay (n = 24; 6 individual drugs, each tested with blood from 4 individual volunteers); each row corresponds to a gene (n = 190) that was found to differ between two or more groups of cultures with individual drugs. The columns are labelled at the bottom according to patient number (1–4) and antibiotic in the culture (by first letter). The antibiotic in each assay is also shown by the colour coding at the top of the column, clearly demonstrating that there is perfect clustering by antibiotic used. Clusters of genes with identifiable pathways are shown as “M” (cell membrane or transmembrane processes; 17 genes), “N” (nucleotide binding, ATP binding, and lipid metabolism; 93 genes); “O” (oxidoreductase; 51 genes)