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Table 2 Concordance analysis data among disk approximation and MIC:MIC ratio methods with time-kill assay according to antimicrobial combinations tested for A. baumannii, P. aeruginosa, and S. marcescens

From: Comparison of methods for the detection of in vitro synergy in multidrug-resistant gram-negative bacteria

Drugs combination/SpeciesDisk approximation and TKMIC:MIC ratio and TK
Acinetobacter baumannii(n = 20)Concordance (%)Kappa/p valueConcordance (%)Kappa/p value
 Colistin with meropenem300.0/0.500400.0
 Colistin with amikacin200.0/0.333350.04/0.25
 Colistin with fosfomycin300.0/0.500NANA
 Fosfomycin with meropenem800.60/0.003NANA
 Fosfomycin with gentamycin75−0.0/0.696NANA
Pseudomonas aeruginosa(n = 28)
 Colistin with meropenem570.0570.0
 Colistin with amikacin930.0680.0
 Meropenem with amikacin640.0NANA
Serratia marcescens(n = 14)
 Colistin with meropenem64−0.12/0.744NANA
 Colistin with amikacin930.0NANA
 Ertapenem with meropenem860.0/0.500710.25/0.081
  1. NA Not applicable