Table 2 Concordance analysis data among disk approximation and MIC:MIC ratio methods with time-kill assay according to antimicrobial combinations tested for A. baumannii, P. aeruginosa, and S. marcescens
Drugs combination/Species | Disk approximation and TK | MIC:MIC ratio and TK | ||
|---|---|---|---|---|
Acinetobacter baumannii(n = 20) | Concordance (%) | Kappa/p value | Concordance (%) | Kappa/p value |
Colistin with meropenem | 30 | 0.0/0.500 | 40 | 0.0 |
Colistin with amikacin | 20 | 0.0/0.333 | 35 | 0.04/0.25 |
Colistin with fosfomycin | 30 | 0.0/0.500 | NA | NA |
Fosfomycin with meropenem | 80 | 0.60/0.003 | NA | NA |
Fosfomycin with gentamycin | 75 | −0.0/0.696 | NA | NA |
Pseudomonas aeruginosa(n = 28) | ||||
Colistin with meropenem | 57 | 0.0 | 57 | 0.0 |
Colistin with amikacin | 93 | 0.0 | 68 | 0.0 |
Meropenem with amikacin | 64 | 0.0 | NA | NA |
Serratia marcescens(n = 14) | ||||
Colistin with meropenem | 64 | −0.12/0.744 | NA | NA |
Colistin with amikacin | 93 | 0.0 | NA | NA |
Ertapenem with meropenem | 86 | 0.0/0.500 | 71 | 0.25/0.081 |