Skip to main content

Table 1 Summary of the phylogenetic analysis

From: Evolutionary analysis of gyrA gene from Neisseria meningitidis bacterial strains of clonal complex 4821 collected in China between 1978 and 2016

GroupWithin
p-dista
Number of sequencesSpecific aa.SpeciesCollection countryYear of collectionSTCCSerogroupCIP resistance phenotype f
Overall0.045226   1931–2017    
Outlier0.143 c,d15L123D; A124G; S139A; V269I; I402M; N411D; M443A; S504AEikenella corrodens (2); N.animaloris (2); N.elongata (2); N.weaveri (2); N.animalis; N.canis; N.elongata subspecies glycolytica; N.mucosa; N.polysaccharea; N.sicca; N.zoodegmatisUSA (2); South Korea (1); Norway (1); Germany (1); France (1); Sweden (1)1954–2017ST3557; ST3706; ST9346; ST9806   
10.062E441H; K455H; S488E; G494S; I509V; E518A; E519DN.meningitidis; N.subflavaChina;?2005–2009ST4832CC4821(1)C (1)I (1)
20.01720N.meningitidisChina2007–2011ST9477; ST5636CC4821; UABR (1)
30.032 b10N.meningitidisChina2009ST12300CC4821BI (1)
40.025 b10N.meningitidisChina2006ST5751UABR
50.04260N.meningitidis (20); N.lactamica (5)China (13); UK (1); USA (1)1992–2014ST5473 (3); ST3493; ST8241; ST4821; ST12316; ST162; ST6930; ST8815; ST5662; ST3436; ST2146; ST8491; ST8920CC4821 (9); UA (2); CC162; CC32; CC198; CC613B (7); C (4); W (2); NGR (11); I (2); S (1)
60.03270N.meningitidis (26); N.cinereaChina2005–2014ST7 (8); ST9454 (2); ST3200 (2); ST5798; ST8241; ST10235; ST5664; ST10446; ST5586; ST5082; ST5084; ST7962; ST6933CC5 (10); CC4821 (8); UA (2); CC77; CC174A (9); B (7); NG (2); E(2); C; XR (19); I (2)
70.00212D210K, E456K, E483K, V486I, N836S, D917GN.gonorrhoeaeCanada (2); USA (2); Japan (1)2010–2015ST1901 (2); ST1903 (2); ST1928; ST7363; ST7367; ST8122; ST8127; ST12536; ST1902  R (5); S (4)
80.003 e1400N.meningitidisChina (125); USA (5); UK (4); Germany (4); Norway (1); France (1); Iceland (1); Benin (1); Gambia (1); South Africa (1); Burkina Faso (1); Canada (1)1931–2016ST4821 (35); ST5 (11); ST11 (5); ST3 (5); ST7 (5); ST3200 (3); ST6933 (2); ST10737 (2); ST32 (2); ST4 (2); ST9454 (2); ST4831 (2); ST5586 (2); ST10; ST10474; ST10607; ST11920; ST12274; ST12276; ST12295; ST12311; ST12314; ST12767; ST12790; ST136; ST177; ST213; ST2146; ST23; ST269; ST2875; ST2881; ST334; ST3436; ST41; ST43; ST4367; ST461; ST4820; ST4896; ST4897; ST4980; ST5242; ST53; ST5464; ST5555; ST5586; ST5610; ST5614; ST5615; ST5632; ST5663; ST5789; ST5798; ST5863; ST5944; ST658; ST6928; ST7303; ST74; ST8445; ST845; ST8789; ST8798; ST9455; ST9456; ST9754; ST9792; ST9936;CC4821 (68); CC5 (16); CC1 (8); UA (8); CC11 (6); CC174 (3); CC32 (3); CC41/44 (3); CC4 (2); CC175 (2); CC103; CC18; CC181; CC198; CC213; CC23; CC269; CC334; CC364; CC4240/6688; CC461; CC53; CC5615; CC8C (43); B (41); A (26); W (8); E (2); NG (1); X (2); Y (2); cnl; IR (28); I(17); S (81)
  1. a- Within p-distance except except b
  2. b- Lowest pairwise p-distance
  3. c- The lowest p-distance between the outlier group and the other 8 groups is 0.16
  4. d- The p-distance within all the sequences except group 8 (86 sequences) is 0.09
  5. e- The p-distance between group 8 and the remaining 86 sequences is 0.066
  6. f- CIP resistance phenotype: R: Resistance; I: Intermediate; S: Susceptible