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Table 1 Dissemination of O. tsutsugamushi in mouse tissuesa

From: Temporal analysis of mRNA expression profiles in Orientia infected C3HeB/FeJ mouse

# of 47 kDa gene/105 mouse cfd gene (fold increase)b

Time post infection

Liver

Spleen

Lung

< day 2

6.8 + 7.5c

NDd

0.8 + 0.4e

Day 4

6.6 + 1.6 (0.97)

6.3 + 3.9 (n/a)g

1.5 + 0.9 (1.9)

Day 7

1473 + 488 (223)

290 + 224 (46.0)

244 + 92 (163)

Day 10f

3.9 × 105 + 1.8 × 105 (264.7)

8701 + 4370 (30.0)

52.4 × 103 + 7.1 × 103 (214.9)

  1. aNumbers represent average of three independent qPCR quantitations of mouse and O. tsutsugamushi copy numbers using cfd and 47 kDa gene, respectively, as described in materials and methods. The number of O. tsutsugamushi 47 kDa gene/105 cfd gene is reported as mean + standard deviation
  2. bNumbers in parentheses represent fold increase over previous time point
  3. cAverage of detectable O. tsutsugamushi 47 kDa gene from 4 hpi, 6 hpi, and 18 hpi samples. Samples from other time points before 2 dpi did not have detectable 47 kDa gene
  4. dND: Not determined
  5. eAverage of detectable O. tsutsugamushi 47 kDa gene from 12 hpi samples. Samples from other time points did not have detectable 47 kDa gene
  6. fOnly two mice had tissues collected to perform qPCR
  7. gNot applicable
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BMC Microbiology

ISSN: 1471-2180

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