Antimicrobial resistance pattern, virulence determinants and molecular analysis of Enterococcus faecium isolated from children infections in Iran

Sattari-Maraji, Azin; Jabalameli, Fereshteh; Node Farahani, Narges; Beigverdi, Reza; Emaneini, Mohammad

doi:10.1186/s12866-019-1539-y

Table 1 Characteristics of E. faecium isolates

From: Antimicrobial resistance pattern, virulence determinants and molecular analysis of Enterococcus faecium isolated from children infections in Iran

Ward^a	Isolate	Time of isolation (m ̸ y)^b	Sample	Resistance pattern^c	Resistance genes	Virulence genes	MLVA type (MT)
Out patient	1	1/2012	Urine	GM, AP, CIP, E, CD	vanA	acm, esp	1
	2	1/2012	Urine	AP, E, CD	–	acm	10
	3	6/2012	Urine	GM, AP, CIP, E, CD	aac(6′)-Ie-aph(2″)-Ia	acm ،ace	1
	4	6/2012	Urine	GM, AP, CIP, E, CD	aac(6′)-Ie-aph(2″)-Ia	acm	1
	5	6/2012	Urine	AP, CIP, E, CD^d	–	acm	1
	6	6/2012	Urine	GM, AP, CIP, E, CD	–	acm	13
	7	9/2012	Urine	GM, AP, CIP, E, CD	vanA	acm	11
	8	10/2012	Urine	AP, CIP, E, CD	–	–	9
	9	6/2013	Urine	GM, AP, CIP, E, CD^d	–	–	17
	10	7/2013	Urine	AP, CIP, E, CD	vanA	acm	1
	11	9/2013	Urine	AP, CIP, E, CD	vanA	acm	1
	12	9/2013	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	13	11/2013	Urine	GM, AP, CIP, E, CD	vanA	acm	1
	14	4/2014	Urine	GM, AP, CIP, E, CD	vanA	acm	1
Urology	15	5/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	20
	16	5/2012	Urine	GM, AP, CIP, E, CD^d	vanA	acm، ace	25
	17	5/2012	Urine	AP, CIP, E, CD^d	–	acm، ace	6
	18	6/2012	Urine	GM, AP, CIP, E, CD	aac(6′)-Ie-aph(2″)-Ia	acm	7
	19	6/2012	Urine	AP, CIP, E, CD	–	–	11
	20	6/2012	Urine	GM, AP, CIP, E, CD	–	acm	8
	21	7/2012	Urine	AP, CIP, E, CD	–	–	23
	22	8/2012	Urine	AP, CIP, E, CD	–	–	4
	23	9/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp	3
	24	10/2012	Urine	GM, AP, CIP, E, CD	–	acm, esp	2
	25	6/2013	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, gelE	1
	26	11/2013	Urine	GM, AP, CIP, E, CD	vanA	acm, esp	3
	27	2/2015	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	2
	28	5/2015	Urine	GM, AP, CIP, E, CD	vanA	acm	3
	29	5/2015	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp	1
Surgery	30	5/2012	CSF	AP, CIP, E, CD	vanA	acm	1
	31	5/2012	CSF	AP, CIP, E, CD	vanA	acm, esp	1
	32	8/2012	Urine	AP, CIP, E, CD	vanA	acm, esp	1
	33	5/2013	Urine	CIP, E	–	acm	27
	34	6/2013	Urine	GM, AP, CIP, E, CD	vanA	acm	1
	35	11/2013	Urine	GM, CIP, E, CD	aac(6′)-Ie-aph(2″)-Ia	asa1, gelE، ace	5
	36	4/2014	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp, gelE	3
	37	1/2015	Urine	GM, AP, CIP, E, CD	vanA	acm, esp	2
	38	4/2015	Urine	AP, CIP, E, CD	vanA	acm, gelE	1
	39	12/2015	Urine	GM, AP, CIP, E, CD	vanA	acm	1
NICU	40	10/2012	Urine	GM, AP, CIP, E, CD	–	–	10
	41	8/2013	Tracheal aspirate	GM, AP, CIP, E, CD	vanA	acm	1
	42	1/2015	Urine	GM, AP, CIP, E, CD	vanA	acm	4
	43	1/2015	Urine	GM, AP, CIP, E, CD^d	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	44	1/2015	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	2
	45	2/2015	Urine	GM, AP, CIP, E, CD	vanA aac(6′)-Ie-aph(2″)-Ia	acm, esp	2
	46	3/2015	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp	1
	47	8/2015	Blood	GM, AP, CIP, E, CD	aac(6′)-Ie-aph(2″)-Ia	acm، ace	1
	48	10/2015	Ascites	GM, AP, CIP, E, CD	vanA	–	2
	49	10/2015	Ascites	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	2
CICU	50	1/2012	Ascites	GM, AP, CIP, E, CD	vanA	acm	1
	51	9/2013	Urine	GM, AP, CIP, E, CD	vanA	–	1
	52	6/2013	Urine	CIP, E, CD	vanA	acm,esp, gelE	2
	53	1/2015	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	2
	54	3/2015	Ascites	GM, AP, CIP, E, CD	–	–	1
	55	5/2015	Urine	GM, AP, CIP, E, CD	vanA	acm	14
	56	6/2015	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm، ace	3
	57	6/2015	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm، ace	1
PICU	58	12/2012	Wound	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp, gelE	3
	59	4/2013	Tracheal aspirate	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	60	1/2014	Wound	GM, AP, CIP, E, CD	vanA	acm	22
	61	3/2014	Blood	GM, AP, CIP, E, CD	vanA	acm, esp	2
	62	11/2014	Ascites	GM, AP, CIP, E, CD	vanA	acm	2
	63	2/2015	Urine	GM, AP, CIP, E, CD	vanA	acm	1
	64	3/2015	Blood	GM, AP, CIP, E, CD^d	vanA	acm	2
	65	6/2015	Dialysis fluid	GM, AP, CIP, E	vanA	acm	1
Dialysis center	66	5/2012	Urine	AP, CIP, E, CD^d	–	acm	1
	67	5/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	68	10/2012	Urine	E, CD	–	asa1	5
	69	1/2013	Catheter	GM, AP, CIP, E, CD	vanA	acm, esp	3
	70	1/2013	Urine	CIP, E, CD^d	–	–	6
	71	6/2013	Urine	AP, CIP, E, CD	–	acm	1
	72	3/2014	Urine	GM, AP, CIP, E, CD	vanA	acm, gelE	4
Neonatal	73	12/2011	Urine	GM, AP, CIP, E, CD	vanA	acm	7
	74	5/2012		GM, AP, CIP, E, CD	vanA	acm	1
	75	6/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	3
	76	9/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	3
	77	9/2012	Urine	GM, AP, CIP, E, CD	vanA	acm	13
	78	12/2013	Urine	GM, AP, CIP, E, CD	vanA	gelE	18
Emeregency	79	1/2012	Urine	E, CD	–	acm	1
	80	1/2012	CSF	GM, AP, CIP, E	aac(6′)-Ie-aph(2″)-Ia	acm	1
	81	1/2012	Urine	GM, AP, CIP, E, CD	–	acm	19
	82	2/2013	Blood	GM, AP, CIP, E, CD	vanA	acm, gelE	1
	83	2/2013	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, gelE	1
	84	2/2013	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, gelE	2
Digestive	85	12/2011	Urine	GM, AP, CIP, E, CD	–	–	5
	86	10/2012	Urine	AP, CIP, E, CD	–	–	9
	87	1/2013	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	2
	88	2/2013	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, gelE	2
Rheumatology	89	2/2013	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp, gelE	3
	90	6/2013	Blood	GM, AP, CIP, E, CD	–	acm	1
	91	11/2015	sputum	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp	3
Neurology	92	3/2012	Urine	GM, AP, CIP, E, CD	vanA	–	21
Oncology	93	9/2015	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
Unknown	94	12/2011	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp	3
	95	3/2012	Urine	GM, AP, CIP, E, CD	vanA	acm	1
	96	5/2012	Urine	GM, AP, CIP, E, CD	–	acm	8
	97	5/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	98	7/2012	Urine	E, CD	–	–	12
	99	7/2012	Blood	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	1
	100	8/2012	Urine	AP, CIP, E	–	–	1
	101	8/2012	Urine	CIP, E, CD	–	acm	12
	102	8/2012	Urine	AP, CIP, E, CD	–	acm	15
	103	8/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm	3
	104	9/2012	Urine	GM, AP, CIP, E, CD	vanA	acm	16
	105	12/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, esp, gelE	3
	106	1/2012	Urine	GM, AP, CIP, E, CD	vanA, aac(6′)-Ie-aph(2″)-Ia	acm, gelE	1
	107	1/2013	Urine	GM, AP, CIP, E, CD	–	acm, gelE	24
	108	1/2013	Urine	AP, CIP, E, CD	–	–	26

^aNICU Neonatal Intensive Care Unit, CICU Coronary Intensive Care Unit; PICU Paediatric Intensive Care Unit
^bm/y month/year, CSF Cerebrospinal fluid
^cGM Gentamicin, AP Ampicillin, CIP Ciprofloxacin, E Erythromycin, CD Clindamycin
^dInducible resistance to clindamycin

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