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Table 3 Distribution of imipenem MIC for P. aeruginosa isolates from the SMART global surveillance programa

From: In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

  MIC μg/mL, n (cumulative %) MIC90
≤0.06 0.125 0.25 0.5 1 2 4 8 16 ≥32
SMART 2009
(n = 993 isolates)
IMI 0 4 (0.4) 12 (1.6) 159 (17.6) 308 (48.6) 196 (68.4) 38 (72.2) 26 (74.8) 100 (84.9) 96 (94.6) ≥32
IMI/RELb 0 14 (1.4) 380 (39.7) 306 (70.5) 78 (78.3) 92 (87.6) 46 (92.2) 18 (94.1) 10 (95.1) 10 (96.1) 4
SMART 2011
(n = 1702 isolates)
IMI 3 (0.2) 4 (0.4) 15 (1.3) 92 (6.7) 596 (41.7) 437 (67.4) 109 (73.8) 73 (78.1) 162 (87.6) 123 (94.8) ≥32
IMI/RELb 5 (0.3) 9 (0.8) 216 (13.5) 883 (65.4) 207 (77.6) 143 (86.0) 108 (92.3) 37 (94.5) 13 (95.2) 13 (96.0) 4
SMART 2015
(n = 5953 isolates)
IMI NDc NDc NDc 1035 (17.4)d 2617 (61.3) 540 (70.4) 246 (74.6) 579 (84.3) 565 (93.8) 371 (100.0) 16
IMI/RELb 58 (1.0) 214 (4.6) 2120 (41.7) 1934 (74.2) 587 (84.0) 453 (91.7) 152 (94.2) 111 (96.1) 53 (97.0) 181 (100.0) 2
SMART 2016
(n = 6165 isolates)
IMI NDc NDc NDc 925 (15.0)d 2593 (57.1) 634 (67.3) 278 (71.9) 567 (81.1) 671 (91.9) 497 (100.0) 16
IMI/RELb 49 (0.8) 169 (3.5) 1875 (33.9) 2299 (71.2) 564 (80.4) 586 (89.9) 154 (92.4) 92 (93.9) 68 (95.0) 309 (100.0) 4
  1. IMI imipenem, IMI/REL imipenem/relebactam, MIC minimum inhibitory concentration, ND not determined
  2. aIncludes SMART surveillance data through October 2018
  3. bImipenem combined with 4 μg/mL of relebactam
  4. cThis MIC value was not tested
  5. dThis value is for ≥0.5 μg/mL, since MIC values < 0.5 μg/mL were not tested