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Table 2 Sensitivity and specificity of WGS-based antimicrobial resistance predictions against the broth microdilution reference AST. Epidemiological cut-offs are applied as interpretive criteria for the reference AST

From: Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods

Antimicrobial

Genotyping sensitivity (95% CI)

Genotyping specificity (95% CI)

Ampicillin

0.96 (0.88–1)

0.93 (0.82–0.99)

Chloramphenicol

0.94 (0.83–0.99)

0.94 (0.84–0.99)

Ciprofloxacin

0.85 (0.66–0.96)

1 (0.95–1)

Gentamicin

0 (0–0.37)

1 (0.96–1)

Nalidixic Acid

0.82 (0.63–0.94)

1 (0.95–1)

Sulfamethoxazole

0.67 (0.54–0.78)

0.97 (0.84–1)

Streptomycin

0.92 (0.83–0.97)

0.83 (0.67–0.94)

Sulfisoxazole

0.62 (0.5–0.73)

0.93 (0.77–0.99)

Trimethoprim-Sulfamethoxazole

0.88 (0.72–0.97)

0.96 (0.88–0.99)

Tetracycline

0.95 (0.85–0.99)

0.82 (0.68–0.92)

Trimethoprim

0.94 (0.79–0.99)

0.97 (0.9–1)

Overall

0.83 (0.79–0.86)

0.96 (0.94–0.97)