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Table 1 Comparison of WGS-based genotyping and phenotypic ASTs against the broth microdilution reference. Frequency of isolates assigned to classification groups after phenotypic testing (broth microdilution) and application of interpretive criteria (epidemiological cut-off and clinical breakpoint). Genotype concordance with classification groups is provided for each interpretive criterion. Antimicrobials with ‘-‘values were not assessed due to the absence of established breakpoints or susceptibility test data

From: Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods

Antimicrobial

Epidemiological cut-off

Clinical breakpoint

Non-Wild Type

Wild Type

Genotype concordance (%)

Resistant

Sensitive

Genotype Concordance (%)

Ampicillin

57

45

95.10

57

45

95.10

Chloramphenicol

49

53

94.12

49

53

94.12

Ciprofloxacin

27

75

96.08

-

-

-

Gentamicin

8

94

92.16

7

95

93.14

Nalidixic Acid

28

74

95.10

28

74

95.10

Sulfamethoxazole

69

33

76.47

69

33

76.47

Streptomycin

66

36

89.22

26

76

55.88

Sulfisoxazole

73

29

70.59

-

-

-

Trimethoprim-Sulfamethoxazole (1:19)

33

69

93.14

30

72

96.08

Tetracycline

57

45

89.22

-

-

-

Trimethoprim

32

70

96.08

-

-

-

Overall

499

623

89.75

266

448

86.55