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Table 2 Changes in SP2–6 metabolites after exposure to different fungicides

From: Use of GC–MS based metabolic fingerprinting for fast exploration of fungicide modes of action

Mode of action group Fungicides Number of metabolites changed (up, down)
Specifically changed Commonly changed
β-tubulins assembly Carbendazim 50 (48, 2) 8 (7, 1)
Thiophanatemethyl 24 (16, 8)
Respiration Boscalid 27 (15, 12) 11 (6, 5)
Kresoxim-methyl 26 (22, 4)
Fluazinam 66 (62, 4)
Mitochondrial function Cyprodinil 4 (1, 3) 17 (1, 16)
Pyrimethanil 8 (1, 7)
Signal transduction Procymidone 22 (21, 1) 25 (15, 10)
Fludioxonil 55 (44, 11)
Membrane sterol biosynthesis Fenhexamid 14 (10, 4) 7 (2, 5)
Imazalil 4 (2, 2)
Multi site action Chlorothalonil 83 (65,18) n.a.
Thiram 37 (15, 22) n.a.
Unknown SYP-14288 20 (15,5) n.a.
  1. Note: The concentration and composition of metabolites were compared between the fungicide treatment and control groups using the one-way ANOVA followed by a Tukey’s test at a significance level of p < 0.05. Metabolites changed column showed the number of metabolites specifically (fungicide specific unique) and commonly regulated within the same mode of action group after treated by different fungicides. “n.a.” means not analysed