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Table 2 Pseudomonas aeruginosa genes differentially regulated between T0 strain and its T48-derivative clones

From: Seawater salt-trapped Pseudomonas aeruginosa survives for years and gets primed for salinity tolerance

Functional classa

Genea

ProbeIDb

Fold changec

Operon IDd

pVal

Adaptation/protection

 Iron-sulfure cluster assembly transcription factor

iscR

PA3815*

2.00

ID777

0.00097

 Bacterioferritin

bfrB

PA3531*

−2.02

 

0.0028

Regulation

 Probable transcriptional regulator

 

PA0547*

2.08

ID118

0.0033

Postranslational modification/degradation

 DNA-specific endonuclease I

endA

PA2749

2.06

 

0.0088

 tRNA (guanine-N(1)-)-methyltransferase

trmD

PA3743*

2.22

ID762

0.00042

 Ribosomal protein L11 methyltransferase

pmrA

PA4850*

2.01

ID996

0.0015

 Regulator of secondary metabolites/Carbon storage regulator

rsmA

PA0905*

−2.23

 

0.0036

Secreted factors

 Exoenzyme S

exoS

PA3841

3.51

 

0.000064

 Exoenzyme T

exoT

PA0044

2.74

 

0.00038

Protein transport and protein secretion (Type III Secretion System)

 Hydrogen ion transportType III secretion system ATPase

 

PA1697

3.40

 

0.00011

 ExsD

exsD

PA1714

2.51

 

0.0033

 ExsC protein secretion export apparatus

exsC

PA1710

2.92

 

0.00077

 Translocation protein

pscP

PA1695

2.21

ID359

0.0048

 Secretion protein

pcr1

PA1699

2.47

ID360

0.0013

 Secretion protein

pcr2

PA1700

2.46

ID360

0.00034

 Secretion protein

pcr3

PA1701*

2.13

ID360

0.00075

 Secretion protein

pcrV

PA1706*

3.27

ID360

0.0000051

 Regulatory protein

pcrH

PA1707*

2.38

ID360

0.00090

 Translocation protein

popB

PA1708*

2.89

ID360

0.00016

 Translocation OMP protein

popD

PA1709*

3.62

ID360

0.000035

 Regulatory protein (exoenzyme S synthesis protein B)

exsB

PA1712*

2.17

ID361

0.0031

 Type III export protein PscD

pscD

PA1717

2.05

ID362

0.018

 Export protein

pscF

PA1719

2.86

ID362

0.00032

 Type III export protein PscJ

pscJ

PA1723

2.34

ID362

0.0043

 Translocation protein

pscO

PA1696

2.18

 

0.0049

Transport of small molecules

 Sulfate transport protein CysW

cysW

PA0281

4.13

 

0.000016

 Probable binding protein component of ABC transporter

 

PA2204

3.84

 

0.0000086

 Na+/alanine/glycine symporter

 

PA2252

3.10

 

0.00029

 Probable MFS dicarboxylate transporter

 

PA5530*

2.67

 

0.00011

 Sulfate transport protein CysT

cysT

PA0282

2.55

 

0.0016

 Probable amino acid permease

 

PA3641

2.46

 

0.0012

 Probable amino acid permease

 

PA0789

2.37

 

0.0076

 Probable ATP-binding component of ABC transporter

 

PA3019*

2.24

 

0.0030

Metabolism/enzymes

 S-adenosylmethionine decarboxylase proenzyme

speD

PA0654*

2.66

 

0.00038

 Aspartate ammonia-lyase

aspA

PA5429

2.56

 

0.0029

 Sulfite reductase

cysI

PA1838

2.47

 

0.0029

 6-phosphogluconolactonase

pgI

PA3182

2.44

 

0.0018

 Soluble pyridine nucleotide transhydrogenase

sth

PA2991

2.35

 

0.0041

 Probable ferredoxin

 

PA1551*

−2.29

ID327

0.0017

 Cytochrome C-oxidase, cbb3-type, CcoP subunit

ccoP2

PA1555*

−2.22

 

0.0041

 Probable cytochrome c oxidase subunit

 

PA1556*

−2.02

ID329

0.0029

 Probable cytochrome oxidase subunit (cbb3-type)

ccoN2

PA1557*

−2.02

ID329

0.0087

 Sulfate adenylyltransferase

cysN

PA4442

2.12

 

0.0029

 NAD-dependent glutamate dehydrogenase

gdhB

PA3068

2.30

 

0.0025

 Glyceraldehyde 3-phosphate dehydrogenase

gapA

PA3195

2.08

 

0.0071

 Co-chaperone HscB

hscB

PA3811

2.62

ID777

0.00063

 Ferredoxin (2Fe-2S)

fdx2

PA3809

2.40

ID777

0.0016

 L-cysteine desulfurase

iscS

PA3814*

2.07

ID777

0.0020

Geranyltranstransferase

ispA

PA4043*

2.14

ID821

0.00087

 N-acetylglucosaminyl transferase

murG

PA4412

2.07

ID903

0.0060

 cytochrome o ubiquinol oxidase, subunit I

cyoB

PA1318

2.04

 

0.0062

 2-keto-3-deoxy-6-phosphogluconate aldolase

 

PA3181

2.02

 

0.013

 Cytochrome o ubiquinol oxidase, subunit III

cyoC

PA1319

2.01

 

0.010

 Sulfate adenylyltransferase subunit 2

cysD

PA4443*

2.66

ID908

0.00026

 Cell division protein FtsJ

ftsJ

PA4752*

−2.00

  

 Probable beta-ketoacyl synthase

 

PA5174

2.19

 

0.00047

 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB

nqrB

PA2998

2.11

 

0.0065

 Ribosomal RNA small subunit methyltransferase C

rsmC

PA4627*

2.39

 

0.0025

Chaperonnes & heat shock proteins

 Molecular chaperone DnaK

dnaK

PA4761*

−2.16

ID978

0.0076

 ATP-dependent protease ATP-binding subunit

hslU

PA5054*

−2.02

 

0.0080

Membran proteins and LPS

 Heptosyltransferase II

waaF

PA5012

2.04

 

0.0096

 RodA rod shape-determining protein

rodA

PA4002

2.04

 

0.011

 Outer membrane protein OprG precursor

oprG

PA4067*

−2.02

 

0.0057

 Na+/H+ ion antiporter subunit

shaD

PA1057*

2.01

ID228

0.0092

Unknown fonction

 Hypothetical protein

 

PA0284

2.23

 

0.0019

 Hypothetical protein

 

PA0310*

−2.02

 

0.0083

 Hypothetical protein

 

PA0570

2.12

ID123

0.0011

 Hypothetical protein

 

PA0915*

2.32

ID197

0.0013

 Hypothetical protein (predicted transmembrane protein)

 

PA1209*

−3.35

 

0.00020

 Hypothetical protein (type II lipoprotein export signal predicted)

 

PA1228

2.35

 

0.0015

 Hypothetical protein (predicted transmembrane protein)

 

PA2501*

−2.64

 

0.0011

 Hypothetical protein (NnrS-like membrane protein)

 

PA2662*

2.13

ID556

0.00048

 Hypothetical protein (predicted transmembrane protein)

 

PA2757*

2.01

 

0.0045

 Hypothetical protein

 

PA3572

−2.23

 

0.00065

 Hypothetical protein (type I lipoprotein export signal predicted)

 

PA4390*

2.16

 

0.0028

 Hypothetical protein (predicted transmembrane protein)

 

PA4517*

−2.42

 

0.00044

 Hypothetical protein

 

PA4611*

−2.22

 

0.0073

 Hypothetical protein

 

PA5446*

−3.18

 

0.00014

  1. aFrom the P. aeruginosa genome project website ( www.pseudomonas.com )
  2. bProbe ORFs identifier for P. aeruginosa PAO1
  3. cFold regulation of P. aeruginosa genes differentially expressed between T0 and T14Y variants
  4. dComputationally predicted operons from the Database of the prokaryotic operons
  5. Asterisks indicate the genes inactivated in the 39 mutants tested for changes in growth in high NaCl concentrations
  6. Underlined genes are those whose inactivation increases growth in high NaCl concentrations
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BMC Microbiology

ISSN: 1471-2180

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