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Table 1 List of 25 most up-regulated genes in the transcriptome of B. thailandensis strain E555 during infection of macrophages after 6 h post-infection

From: Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages

Bt E555 fig|869,728.6. peg.

log2 fold change in T6 transcriptome

Bt E555 gene function assigned by RAST

Bp Sanger ID

Bp gene name

Bp gene product

Significantly upregulated in T5 transcriptome?

Significantly upregulated in T6 proteome?

5909

11.7106

Hcp

BPSS1498

tssD-5 (hcp1)

type VI secretion system protein TssD-5

Yes

Yes

5896

9.5536

N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28)

BPSS1490

N-acetylmuramoyl-L-alanine amidase

Yes

Yes

5907

9.3004

Uncharacterized protein ImpB

BPSS1496

tssB-5

type VI secretion system protein TssB-5

Yes

Yes

5908

9.0842

Uncharacterized protein ImpC

BPSS1497

tssC-5

type VI secretion system protein TssC-5

Yes

Yes

5910

8.9729

Uncharacterized protein similar to VCA0109

BPSS1499

tssE-5

type VI secretion system protein TssE-5

Yes

 

5897

8.5387

Plasmid pIB6 ORFA DNA

BPSS1491

hypothetical protein

Yes

Yes

2756

8.4671

TonB-dependent hemin, ferrichrome receptor

BPSS0244

BhuR (Outer membrane heme receptor)

Yes

No

5913

8.4574

ClpB protein

BPSS1502

tssH-5

type VI secretion system protein TssH-5

Yes

No

5911

8.1660

Protein ImpG/VasA

BPSS1500

tssF-5

type VI secretion system protein TssF-5

Yes

No

3093

8.0481

SyrP-like protein

BPSL1785

hypothetical protein

Yes

Yes

3100

7.8577

ABC-type siderophore export system, fused ATPase and permease components

BPSL1779

siderophore biosynthesis related ABC transport protein

Yes

No

3113

7.4295

Non-ribosomal peptide synthetase modules, pyoverdine

BPSL1778

siderophore related no-ribosomal peptide synthase

No

No

5914

7.3994

VgrG protein

BPSS1503

tssI-5

type VI secretion protein TssI-5

Yes

No

5915

7.2906

hypothetical protein

BPSS1504

tagAB-5

type VI secretion system-associated protein TagAB-5

Yes

Yes

5839

7.2027

Fig. 00464790: hypothetical protein

BPSL3352

hypothetical protein

Yes

 

5920

7.1177

Uncharacterized protein ImpJ/VasE

BPSS1509

tssK-5

type VI secretion system protein TssK-5

Yes

Yes

5922

7.0900

IcmF-related protein

BPSS1511

tssM-5

type VI secretion system protein TssM-5

Yes

Yes

6277

7.0886

Hemin uptake protein

BPSS0362

hypothetical protein

Yes

No

3095

6.9269

Ferrichrome transport system permease protein FhuB (TC 3.A.1.14.3)

BPSL1783

iron-hydroxamate transporter permease subunit

No

No

5952

6.7155

Type III secretion thermoregulatory protein (LcrF,VirF,transcription regulation of virulence plasmid)

BPSS1546

bsaN

regulator of type III secretion system effector proteins BsaN (T3SS-3)

Yes

No

5900

6.4369

Fig. 00456189: hypothetical protein

no homolog

  

Yes

No

5899

6.4344

Autotransporter adhesin

BPSS1492

bimA

Burkholderia intracellular motility A, BimA

Yes

Yes

5919

6.1933

putative lipoprotein

BPSS1508

tssJ-5

type VI secretion system protein TssJ-5

Yes

Yes

3092

6.1826

hypothetical MbtH-like protein, PA2412 homolog

BPSL1786

hypothetical protein

Yes

No

5927

6.1495

DNA-binding response regulator

BPSS1522

bprB

two-component response regulator

Yes

No

  1. Known virulence factors of B. pseudomallei are shown in bold in the first column