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Table 2 Selected KEGG pathways (KEGG orthology level 3) in cecal samples being differently enriched in CON- and TGS-fed pigs

From: Functional adaptations in the cecal and colonic metagenomes associated with the consumption of transglycosylated starch in a pig model

KEGG pathway Meana log2 fold change SEb p value q value
00633 Nitrotoluene degradation [PATH:ko00633] 389 1.982 0.375 < 0.001 < 0.001
00983 Drug metabolism - other enzymes [PATH:ko00983] 1046 1.772 0.353 < 0.001 < 0.001
00940 Phenylpropanoid biosynthesis [PATH:ko00940] 9129 1.613 0.213 < 0.001 < 0.001
02060 Phosphotransferase system (PTS) [PATH:ko02060] 6289 1.040 0.217 < 0.001 < 0.001
00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:ko00130] 3982 0.969 0.224 < 0.001 < 0.001
00040 Pentose and glucuronate interconversions [PATH:ko00040] 14,629 0.803 0.191 < 0.001 < 0.001
04141 Protein processing in endoplasmic reticulum [PATH:ko04141] 803 0.789 0.193 < 0.001 < 0.001
00052 Galactose metabolism [PATH:ko00052] 20,395 0.739 0.125 < 0.001 < 0.001
00051 Fructose and mannose metabolism [PATH:ko00051] 17,994 0.673 0.126 < 0.001 < 0.001
00730 Thiamine metabolism [PATH:ko00730] 9877 0.607 0.125 < 0.001 < 0.001
02010 ABC transporters [PATH:ko02010] 49,093 −0.413 0.075 < 0.001 < 0.001
03013 RNA transport [PATH:ko03013] 1493 −0.453 0.112 < 0.001 < 0.001
04122 Sulfur relay system [PATH:ko04122] 5609 −0.976 0.197 < 0.001 < 0.001
00360 Phenylalanine metabolism [PATH:ko00360] 2011 −1.286 0.311 < 0.001 < 0.001
02040 Flagellar assembly [PATH:ko02040] 7812 −1.370 0.269 < 0.001 < 0.001
00380 Tryptophan metabolism [PATH:ko00380] 255 −1.651 0.294 < 0.001 < 0.001
00531 Glycosaminoglycan degradation [PATH:ko00531] 391 1.077 0.275 < 0.001 0.001
00860 Porphyrin and chlorophyll metabolism [PATH:ko00860] 7948 0.594 0.152 < 0.001 0.001
00680 Methane metabolism [PATH:ko00680] 4678 −0.375 0.096 < 0.001 0.001
00630 Glyoxylate and dicarboxylate metabolism [PATH:ko00630] 3354 −0.418 0.108 < 0.001 0.001
03070 Bacterial secretion system [PATH:ko03070] 24,985 −0.367 0.104 < 0.001 0.002
00500 Starch and sucrose metabolism [PATH:ko00500] 18,633 −0.245 0.075 0.001 0.006
04142 Lysosome [PATH:ko04142] 3227 0.593 0.187 0.002 0.007
00350 Tyrosine metabolism [PATH:ko00350] 2333 −0.932 0.294 0.002 0.007
00511 Other glycan degradation [PATH:ko00511] 2316 0.665 0.214 0.002 0.008
04151 PI3K-Akt signaling pathway [PATH:ko04151] 5164 −0.822 0.267 0.002 0.009
00590 Arachidonic acid metabolism [PATH:ko00590] 829 1.026 0.351 0.003 0.014
00300 Lysine biosynthesis [PATH:ko00300] 23,314 0.136 0.047 0.004 0.014
00510 N-Glycan biosynthesis [PATH:ko00510] 918 0.545 0.202 0.007 0.024
00564 Glycerophospholipid metabolism [PATH:ko00564] 5568 0.154 0.057 0.007 0.024
00010 Glycolysis / Gluconeogenesis [PATH:ko00010] 23,481 −0.160 0.059 0.007 0.024
00061 Fatty acid biosynthesis [PATH:ko00061] 13,010 −0.165 0.061 0.007 0.024
00330 Arginine and proline metabolism [PATH:ko00330] 26,554 0.284 0.106 0.007 0.025
00071 Fatty acid metabolism [PATH:ko00071] 133 −1.077 0.423 0.011 0.036
00900 Terpenoid backbone biosynthesis [PATH:ko00900] 12,834 0.216 0.086 0.012 0.037
00020 Citrate cycle (TCA cycle) [PATH:ko00020] 15,173 0.415 0.171 0.015 0.045
03020 RNA polymerase [PATH:ko03020] 29,030 −0.385 0.159 0.015 0.045
02030 Bacterial chemotaxis [PATH:ko02030] 8461 −0.680 0.278 0.015 0.045
03060 Protein export [PATH:ko03060] 1992 0.193 0.083 0.020 0.056
00520 Amino sugar and nucleotide sugar metabolism [PATH:ko00520] 18,729 0.147 0.064 0.022 0.062
00280 Valine leucine and isoleucine degradation [PATH:ko00280] 5486 −0.240 0.108 0.026 0.067
00785 Lipoic acid metabolism [PATH:ko00785] 167 −0.642 0.287 0.025 0.067
00030 Pentose phosphate pathway [PATH:ko00030] 12,994 −0.128 0.058 0.027 0.068
00750 Vitamin B6 metabolism [PATH:ko00750] 4284 0.280 0.131 0.033 0.077
00540 Lipopolysaccharide biosynthesis [PATH:ko00540] 10,816 0.615 0.292 0.035 0.081
00908 Zeatin biosynthesis [PATH:ko00908] 2398 0.174 0.085 0.040 0.091
04146 Peroxisome [PATH:ko04146] 6168 −0.179 0.088 0.041 0.091
00053 Ascorbate and aldarate metabolism [PATH:ko00053] 334 0.498 0.250 0.046 0.099
03018 RNA degradation [PATH:ko03018] 30,822 −0.183 0.092 0.046 0.099
  1. False discovery rate (Benjamini-Hochberg) corrected p value
  2. aNormalized reads (hit counts). Only the most abundant KEGG pathways (> 0.01% of all reads) that were altered by the dietary starch source are presented (n = 8 per diet)
  3. bStandard error of the log2fold change