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Table 4 Proteins associated with copper response in P. aeruginosa PAO1 whole cell lysate. Protein samples from the copper stressed PAO1 were compared against the control group (+/− 1.5 –fold abundance change, p < 0.01)

From: Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress

Protein

Fold change (+/−)

p-value

Peptides

Product Description

Subcellular Localization (localization [confidence code])*

Product Name Confidence

PA3661

63.0

< 0.0001

2

Hypothetical protein

Unknown [Class 3]

Class 4

PA2505

25.1

< 0.0001

10

Tyrosine porin OpdT

Outer Membrane [Class 2]; Outer Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 1

PA4714

16.2

0.002

5

Conserved hypothetical protein

Unknown (This protein may have multiple localization sites) [Class 3]; Unknown (This protein may have multiple localization sites) [Class 3]

Class 4

PA2064

10.8

< 0.0001

6

Copper resistance protein B precursor

Outer Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA2405

10.3

0.003

1

FpvJ

Unknown [Class 3]

Class 1

PA3412

10.2

0.005

3

Hypothetical protein

Unknown [Class 3]

Class 4

PA2807

10.1

0.004

4

Hypothetical protein

Unknown [Class 3]

Class 4

PA4224

6.6

0.002

6

Pyochelin biosynthetic protein PchG

Cytoplasmic [Class 3]

Class 1

PA3445

6.2

0.002

3

Conserved hypothetical protein

Unknown (This protein may have multiple localization sites) [Class 3]; Unknown (This protein may have multiple localization sites) [Class 3]

Class 4

PA4884

4.9

0.004

4

Hypothetical protein

Periplasmic [Class 3]

Class 4

PA2065

4.4

< 0.0001

8

Copper resistance protein A precursor

Periplasmic [Class 2]; Periplasmic [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA3920

4.0

0.003

2

Probable metal transporting P-type ATPase

Cytoplasmic Membrane [Class 3]

Class 3

PA3182

3.0

0.008

2

6-phosphogluconolactonase

Unknown [Class 3]

Class 1

PA0283

2.8

0.009

10

Sulfate-binding protein precursor

Periplasmic [Class 2]; Periplasmic [Class 3]

Class 2

PA3450

2.8

0.001

6

Probable antioxidant protein

Cytoplasmic [Class 3]

Class 3

PA0346

2.5

0.004

6

Hypothetical protein

Unknown [Class 3]

Class 4

PA4923

2.3

0.010

2

Conserved hypothetical protein

Unknown [Class 3]

Class 4

PA3165

2.0

0.007

5

Histidinol-phosphate aminotransferase

Cytoplasmic [Class 3]

Class 2

PA5215

1.9

0.006

1

Glycine-cleavage system protein T1

Cytoplasmic [Class 3]

Class 2

PA5335

1.7

0.005

1

Conserved hypothetical protein

Cytoplasmic [Class 3]

Class 4

PA4240

1.7

0.009

3

30S ribosomal protein S11

Cytoplasmic [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA0473

1.7

0.006

2

Probable glutathione S-transferase

Cytoplasmic [Class 3]

Class 3

PA5188

1.7

0.010

2

Probable 3-hydroxyacyl-CoA dehydrogenase

Cytoplasmic [Class 3]

Class 3

PA3029

1.6

0.007

5

Molybdopterin biosynthetic protein B2

Cytoplasmic [Class 3]

Class 2

PA4110

1.6

0.010

5

Beta-lactamase precursor (AmpC)

Periplasmic [Class 1]; Periplasmic [Class 3]

Class 1

PA1024

1.6

< 0.0001

1

2-Nitropropane Dioxygenase

Cytoplasmic [Class 3]

Class 1

PA3896

1.6

0.001

2

Probable 2-hydroxyacid dehydrogenase

Cytoplasmic [Class 2]; Cytoplasmic [Class 3]

Class 3

PA4947

1.5

0.007

1

N-acetylmuramoyl-L-alanine amidase

Unknown [Class 3]

Class 2

PA1151

1.5

0.005

3

Pyocin S2 immunity protein

Cytoplasmic [Class 3]

Class 1

PA3243

1.5

0.001

3

Cell division inhibitor MinC

Cytoplasmic [Class 3]

Class 2

PA2572

−1.6

0.008

1

Probable two-component response regulator

Cytoplasmic [Class 3]

Class 3

PA0833

−1.6

0.008

2

Hypothetical protein

Outer Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 4

PA2476

−1.7

0.008

3

Thiol:disulfide interchange protein DsbG

Periplasmic [Class 3]

Class 2

PA5209

−1.9

0.001

2

Hypothetical protein

Unknown (This protein may have multiple localization sites) [Class 3]; Unknown (This protein may have multiple localization sites) [Class 3]

Class 4

PA5562

−1.9

0.002

5

Chromosome partitioning protein Spo0J

Cytoplasmic [Class 3]

Class 2

PA0265

−2.0

0.004

3

Succinate-semialdehyde dehydrogenase

Cytoplasmic [Class 3]

Class 2

PA5554

−2.0

< 0.0001

15

ATP synthase beta chain

Cytoplasmic [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA2259

−2.1

0.006

1

Transcriptional regulator PtxS

Cytoplasmic [Class 3]

Class 1

PA4317

−2.2

0.006

1

Hypothetical protein

Cytoplasmic Membrane [Class 3]

Class 4

PA4764

−2.3

0.008

2

Ferric uptake regulation protein

Cytoplasmic [Class 1]; Cytoplasmic [Class 3]

Class 1

PA1580

−2.3

0.009

5

Citrate synthase

Cytoplasmic [Class 3]

Class 1

PA4360

−2.4

0.008

2

Hypothetical protein

Unknown [Class 3]; Outer Membrane Vesicle [Class 1]

Class 4

PA1608

−2.5

0.008

2

Probable chemotaxis transducer

Cytoplasmic Membrane [Class 3]; Outer Membrane [Class 2]

Class 3

PA3214

−2.7

0.002

2

Hypothetical protein

Unknown [Class 3]

Class 4

PA0762

−2.7

0.007

2

Sigma factor AlgU

Cytoplasmic [Class 3]

Class 1

PA0122

−2.8

0.003

4

rahU

Extracellular [Class 3]

Class 1

PA4310

−2.9

0.004

3

Chemotactic transducer PctB

Cytoplasmic Membrane [Class 3]

Class 1

PA2654

−3.2

0.008

6

Probable chemotaxis transducer

Cytoplasmic Membrane [Class 3]

Class 3

PA2815

−4.2

0.006

4

Probable acyl-CoA dehydrogenase

Cytoplasmic Membrane [Class 3]; Outer Membrane Vesicle [Class 1]

Class 3

PA4876

−4.7

0.003

2

Osmotically inducible lipoprotein OsmE

Unknown [Class 3]; Outer Membrane Vesicle [Class 1]

Class 2

PA1324

−6.1

0.003

5

Hypothetical protein

Unknown [Class 3]

Class 4

PA3691

−6.2

0.009

8

Hypothetical protein

Unknown [Class 3]; Outer Membrane Vesicle [Class 1]

Class 4

PA3110

−16.7

< 0.0001

1

Hypothetical protein

Unknown [Class 3]

Class 4

  1. *Extracted from PGD. Class 1: Subcellular localization experimentally demonstrated in Pseudomonas aeruginosa. Class 2: Subcellular localization of a similar gene experimentally demonstrated in another organism OR to a paralog experimentally demonstrated in the same organism. BLAST expect value of 10e-10 for query within 80–120% of subject length. Class 3: Subcellular localization computationally predicted by PSORTb [44]. Bold indicates first time evidence of protein translation in PAO1
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BMC Microbiology

ISSN: 1471-2180

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