Table 4 In vitro activity of erava against S aureus with Tet specific resistant genes
Tet resistance factors | N | Tetracycline | Erava | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
No. isolates with each MIC (mg/L) | No. isolates with each MIC (mg/L) | MIC range | MIC50/MIC90 | |||||||
≤4.0 | 8.0 | ≥16.0 | ≤0.125 | 0.25 | 0.5 | 1.0 | ||||
MRSA | ||||||||||
 Tet(M) | 27 | 1 | 1 | 25 | 10 | 17 | 0 | 1 | ≤0.125–0.25 | 0.25/0.25 |
 Tet(K) | 27 | 3 | 8 | 16 | 2 | 24 | 3 | 0 | 0.0625–0.5 | 0.25/0.5 |
 Tet(L) | 5 | 0 | 1 | 4 | 1 | 4 | 0 | 0 | 0.125–0.25 | 0.25/0.25 |
 Tet(M), Tet(L) | 4 | 0 | 1 | 3 | 0 | 4 | 0 | 0 | 0.25 | 0.25/0.25 |
 Tet(L), Tet(K) | 3 | 0 | 3 | 0 | 2 | 1 | 0 | 0 | 0.125–0.25 | ND |
 Tet(M), Tet(K) | 2 | 0 | 0 | 2 | 0 | 1 | 1 | 0 | 0. 25–0.5 | ND |
 Tet(M), Tet(L), Tet(K) | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0.0625 | ND |
-a | 69 | 43 | 3 | 23 | 38 | 29 | 2 | 0 | 0.0625–0.5 | 0.125/0.25 |
MSSA | ||||||||||
 Tet(M) | 2 | 2 | 0 | 0 | 1 | 1 | 0 | 0 | ≤0.125–0.25 | ND |
 Tet(K) | 63 | 14 | 10 | 39 | 12 | 33 | 17 | 1 | 0.0625–1.0 | 0.25/0.5 |
 Tet(L) | 2 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0.5 | ND |
 Tet(L), Tet(K) | 5 | 1 | 0 | 4 | 1 | 0 | 3 | 1 | 0.125–1.0 | 0.5/0.5 |
 Tet(M), Tet(K) | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0.5 | ND |
-a | 115 | 94 | 1 | 20 | 76 | 32 | 6 | 1 | 0.0625–1.0 | 0.125/0.5 |