Table 2 The SMICs of amphotericin B and caspofungin in C. albicans biofilms
Farnesol (μM) | amphotericin B(μg/ml) | caspofungin(μg/ml) | ||||
|---|---|---|---|---|---|---|
CAI4-pCaEXP | CYR1OE | PDE2OE | CAI4-pCaEXP | CYR1OE | PDE2OE | |
6 h | ||||||
 0 | 1 | 4 | 4 | 0.125 | 0.125 | 8 |
 50 | 1 | 4 | 4 | 0.125 | 0.125 | 8 |
 100 | 0.5 | 2 | 4 | 0.0625 | 0.0625 | 8 |
 200 | 1 | 4 | 2 | 0.0625 | 0.0625 | 0.625 |
 300 | 1 | 4 | 1 | 0.0625 | 0.0625 | 0.25 |
 600 | 1 | 4 | 1 | 0.0625 | 0.0625 | 0.25 |
 1200 | 1 | 2 | 1 | 0.0625 | 0.125 | 0.125 |
12 h | ||||||
 0 | 0.5 | 8 | 4 | > 8 | > 8 | 0.0625 |
 50 | 0.5 | 4 | 4 | > 8 | 8 | 0.0625 |
 100 | 0.5 | 4 | 2 | > 8 | > 8 | 0.0625 |
 200 | 0.5 | 4 | 2 | 0.25 | 8 | 0.0625 |
 300 | 1 | 4 | 2 | 0.25 | 0.0625 | 0.0625 |
 600 | 1 | 8 | 1 | 0.25 | 0.0625 | 0.0625 |
 1200 | 16 | 8 | 2 | 0.0625 | 0.125 | 0.0625 |
24 h | ||||||
 0 | 1 | > 16 | 1 | > 8 | > 8 | > 8 |
 50 | 1 | 16 | 1 | > 8 | 8 | > 8 |
 100 | 1 | 16 | 1 | > 8 | 0.125 | > 8 |
 200 | 0.5 | 8 | 1 | > 8 | 0.0625 | 0.25 |
 300 | 1 | 8 | 1 | > 8 | 0.0625 | 0.0625 |
 600 | 0.125 | 8 | 1 | 2 | 0.0625 | 0.125 |
 1200 | 0.125 | 8 | 1 | > 8 | 0.0625 | 0.125 |
36 h | ||||||
 0 | 0.25 | 16 | 16 | > 8 | > 8 | > 8 |
 50 | 0.25 | 16 | 16 | 4 | 1 | > 8 |
 100 | 2 | 8 | 8 | 1 | 0.5 | > 8 |
 200 | 0.125 | 4 | 4 | 0.25 | 0.5 | 0.125 |
 300 | 0.125 | 4 | 4 | 0.125 | 0.5 | 0.125 |
 600 | 0.25 | 4 | 2 | 0.0625 | 0.5 | 0.25 |
 1200 | 0.125 | 4 | 2 | 4 | 0.5 | 0.5 |