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Table 2 The SMICs of amphotericin B and caspofungin in C. albicans biofilms

From: The possible molecular mechanisms of farnesol on the antifungal resistance of C. albicans biofilms: the regulation of CYR1 and PDE2

Farnesol (μM) amphotericin B(μg/ml) caspofungin(μg/ml)
CAI4-pCaEXP CYR1OE PDE2OE CAI4-pCaEXP CYR1OE PDE2OE
6 h
 0 1 4 4 0.125 0.125 8
 50 1 4 4 0.125 0.125 8
 100 0.5 2 4 0.0625 0.0625 8
 200 1 4 2 0.0625 0.0625 0.625
 300 1 4 1 0.0625 0.0625 0.25
 600 1 4 1 0.0625 0.0625 0.25
 1200 1 2 1 0.0625 0.125 0.125
12 h
 0 0.5 8 4 > 8 > 8 0.0625
 50 0.5 4 4 > 8 8 0.0625
 100 0.5 4 2 > 8 > 8 0.0625
 200 0.5 4 2 0.25 8 0.0625
 300 1 4 2 0.25 0.0625 0.0625
 600 1 8 1 0.25 0.0625 0.0625
 1200 16 8 2 0.0625 0.125 0.0625
24 h
 0 1 > 16 1 > 8 > 8 > 8
 50 1 16 1 > 8 8 > 8
 100 1 16 1 > 8 0.125 > 8
 200 0.5 8 1 > 8 0.0625 0.25
 300 1 8 1 > 8 0.0625 0.0625
 600 0.125 8 1 2 0.0625 0.125
 1200 0.125 8 1 > 8 0.0625 0.125
36 h
 0 0.25 16 16 > 8 > 8 > 8
 50 0.25 16 16 4 1 > 8
 100 2 8 8 1 0.5 > 8
 200 0.125 4 4 0.25 0.5 0.125
 300 0.125 4 4 0.125 0.5 0.125
 600 0.25 4 2 0.0625 0.5 0.25
 1200 0.125 4 2 4 0.5 0.5