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Table 1 In vitro susceptibility of C. albicans biofilms to antifungals

From: The possible molecular mechanisms of farnesol on the antifungal resistance of C. albicans biofilms: the regulation of CYR1 and PDE2

Strains SMIC50 of antifungals (μg/ml)
6 h 12 h 24 h 36 h
amphotericin B
 CAI4-pCaEXP 1 0.5 1 0.25
 CYR1OE 4 8 > 16 16
 PDE2OE 4 4 1 16
caspofungin
 CAI4-pCaEXP 0.125 > 8 > 8 > 8
 CYR1OE 0.125 > 8 > 8 > 8
 PDE2OE 8 > 8 > 8 > 8
itraconazole
 CAI4-pCaEXP > 16 > 16 > 16 > 16
 CYR1OE > 16 > 16 > 16 > 16
 PDE2OE > 16 > 16 > 16 > 16
terbinafine
 CAI4-pCaEXP > 256 > 256 > 256 > 256
 CYR1OE > 256 > 256 > 256 > 256
 PDE2OE > 256 > 256 > 256 > 256