Fig. 4

Certain metabolic pathways are enriched for the correlated enzyme functions. a A pathway diagram showing part of the KEGG pathway “ubiquinone and other terpenoid-quinone biosynthesis pathway” (map00130). Enzymes whose occurrence are significantly correlated with growth temperature (corrected p-value < 0.01) are shown in red (positive correlation) or blue (negative correlation). b The presence of enzymes participating in the biosynthesis of Ubiquinone changes with temperature. Each point indicates the occurrence of the EC number as a ratio of its presence in all organisms growing at a specific temperature. The line represents locally weighted polynomial regression with a 95% confidence band for the regression line indicated in gray. r indicates Spearman’s correlation coefficient. c The presence of enzymes participating in the biosynthesis of menaquinone via the futalosine pathway changes with temperature. d The presence of enzymes participating in the biosynthesis of menaquinone via the classical pathway changes with temperature