Fig. 3

Differentially enriched MGS, Control versus asthma: For all MGSs with more than 700 genes, the orientation of enrichment was determined by two-tailed Wilcoxon-rank sum test ((U statistic of two-tail Wilcoxon rank-sum test, P < 0.05, FDR < 0.2, Effect size equal to (\( 1-\frac{2U}{nm}\Big) \), Additional file 5: Table S3). Size of the nodes consistent with the number of genes (700~ 3645) in the MGSs. MGSs annotated to species were colored according to enrichment. Edges between nodes indicated Spearman’s correlation > 0.3 (red) or < − 0.3 (blue), calculated according to the samples under comparison