Table 4 Prevalence and mutation profile in katG, inhA and ahpC genes in INH-resistant strains in Kyrgyzstan
Gene | Codon | Amino acid replacement | Nucleotide replacement | N = 114 (%) | N (%) |
|---|---|---|---|---|---|
katG | 315 | Ser315→Thr | AGC → ACC | 101 (88.6) | 104 (91.2) |
Ser315→Asn | AGC → AAC | 2 (1.7) | |||
Ser315→Arg | AGC → CGC | 1 (0.9) | |||
inhA | 15 | inhA T_15 | C → T | 8 (7) | 8 (7) |
ahpC | 9 | AhpC_9 | G → A | 1 (0.9) | 2 (1.8) |
12 | AhpC_12 | C → T | 1 (0.9) |