Genome sequencing and comparative genomics of enterohemorrhagic Escherichia coli O145:H25 and O145:H28 reveal distinct evolutionary paths and marked variations in traits associated with virulence & colonization

Table 3 Fimbrial gene clusters present in EHEC O145:H25 and other E. coli strains

Fimbrial cluster	O145:H25		O145:H28		O26:H11	O103:H2	O111:HNM	O157:H7	O165:H25	commensal
Fimbrial cluster	CFSAN004176	CFSAN004177	RM13514	RM13516	11,365	12,009	11,128	Sakai	2012C-4227	HS
F01	+	+	+	+	+	+	+	H	+	+
F02	+	+	H^a	H^a	H^b	+	H^b	H^c	H^b	H^b
F03	(+)	(+)	−	−	+	+	(+)	−	(+)	+
F04	+	+	−	−	(+)	+	+	−	+	+
F05 (OI-127)	+	+	−	−	+	+	+	(+)	+	+
F06 (Lpf_O113/OI-154)	+	+	−	−	+	−	+	H	+	−
F07	+	+	+	+	+	+	+	+	+	+
F08 (OI-1)	(+/−)	(+/−)	(+)	(+)	(+/−)	(+/−)	(+/−)	(+)	(+/−)	(+/−)
F09	+	+	+	+	+	+	+	+	+	+
F10	+	+	H^d	H^d	+	+	+	H^d	(+)	(+/−)
F11	+	(+)	+	+	+	+	−	+	−	(+/−)
F12	+	+	+	+	+	+	+	+	+	+
F13	+	+	H^e	H^e	+	(+)	+	H^e	+	+
F14	+	+	+	+	+	(+)	+	(+)	(+)	+
F15	+	+	+	(+)	+	+	+	+	(+)	(+)
F16 (OI-61)	(+/−)	(+/−)	+	(+/−)	+	(+/−)	+	+	(+/−)	(+/−)
F17 (OI-141)	−	−	(+)	+	H^f	H^f	H^f	(+)	−	−
F18 (OI-47)	−	−	(+/−)	(+/−)	−	−	−	+	−	−
F19 (sfp cluster)	+	+	−	−	−	−	−	−	+	−
Total^g	15 (2)	15 (2)	13 (1)	12 (2)	16 (1)	14 (2)	15 (1)	16	14 (2)	11 (4)

+, present (> 90% identity, > 90% gene coverage); −, absent; (+/−), partial; (+), contains pseudogene(s); H homolog (< 90% sequence identity); (see also Additional file 3: Table S3)
^{a, b, c, d, e, f}same letters indicate same homolog
^gnumbers in parentheses indicate the number of partially conserved clusters

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