Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort

BMC Microbiology

Table 3 Regression analysis between gut microbiota and BMI levels

Overweight vs. Normal	Age- and sex- adjusted		Multivariate adjusted
Overweight vs. Normal	Coefficient^a	Adj. P value^b	Coefficient^a	P value	Adj. P value^b
Cyanobacteria YS2^c	0.618	2.63 × 10⁻⁹	0.035	0.700	1
Desulfovibrio ^d	0.435	9.08 × 10⁻⁵	−0.101	0.273	1
Bacteroidales unknown family unknown genus^d	0.403	2.48 × 10⁻⁴	0.314	0.001	0.068
Paraprevotellaceae CF231^c	0.360	4.58 × 10⁻⁴	0.463	2.13 × 10 ⁻⁷	1.51 × 10 ⁻⁵
Acidaminococcus ^d	0.331	0.002	−0.073	0.403	1
Lactobacillales unknown family unknown genus^c	0.174	0.031	0.080	0.333	1
Lactococcus ^e	0.152	0.042	0.099	0.064	1
Eggerthella ^e	−0.155	0.005	−0.103	0.022	1
Obese vs. Normal
Acidaminococcus ^d	0.498	3.90 × 10⁻⁸	0.378	2.89 × 10 ⁻⁵	0.002
Paraprevotellaceae CF231^c	0.463	7.32 × 10⁻⁶	0.284	0.003	0.181
Megasphaera ^e	0.443	1.79 × 10⁻⁵	0.355	0.002	0.146
Mitsuokella ^c	0.302	0.034	0.217	0.013	0.946
Eggerthella ^e	−0.162	0.003	−0.073	0.356	1
Christensenellaceae unknown genus^d	−0.152	0.031	−0.055	0.003	0.230
Clostridiales unknown family unknown genus	−0.063	0.004	−0.063	5.24 × 10 ⁻⁵	0.004
Obese vs. Overweight
Acidaminococcus ^d	0.329	0.001	0.504	2.64 × 10 ⁻⁸	1.87 × 10 ⁻⁶
Mitsuokella ^c	0.271	0.007	0.381	1.10 × 10 ⁻⁶	2.61 × 10 ⁻⁵
Akkermansia	−0.225	0.038	−0.225	0.001	0.038
Christensenellaceae unknown genus^d	−0.179	0.003	−0.170	0.020	0.126
Adlercreutzia	0.139	0.007	0.139	9.34 × 10 ⁻⁵	0.007

^aCoefficient (log2 ratio) driven by zero-inflated Gaussian mixture model (fitZig) using metageomeSeq package
^bApplied by Bonferroni multiple comparison correction
^cAdditionally adjusted for fat and total calorie intake
^dAdditionally adjusted for fiber and total calorie intake
^eAdditionally adjusted for carbohydrate and total calorie intake
Coefficient with Adj. P value < 0.05 shown in italic

ISSN: 1471-2180