Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis

Table 2 Gene products involved in transformation and pilus biogenesis that were differentially abundant in the Nm ΔdprA mutant compared to the wildtype when identified by mass spectrometry

Genes	Protein name	Protein fold change
pilG ^a	Pilus assembly protein PilG	-50.33
pilT-2 ^a	Twitching motility protein PilT	-14.24
pilT-1 ^a	Twitching motility protein PilT	-11.75
pilM ^a	PilM protein	-6.24
NMB0051 (pilU)	Twitching motility protein	-3.24
pilF	Type IV pilus assembly protein	-2.88
pilO	PilO protein	-2.57
pilN	PilN protein	-1.08
NMB0889 (pilX)	pilus assembly protein	-1.05
NMB0888 (pilW)	Putative type IV pilus assembly protein	+1.07
pilP	PilP protein	+1.39
pilQ	Type IV pilus biogenesis and competence protein PilQ	+1.50
NMB1309	Putative fimbrial biogenesis and twitching motility protein	+1.54
pilE	Fimbrial	+1.61

^aSignificantly downregulated proteins in the ΔdprA mutant. The minus sign of the protein fold change indicates the downregulated whereas the positive sign upregulated proteins

ISSN: 1471-2180