Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis

Table 1 The 3R (replication, recombination and repair) gene products that were differentially abundant in the Nm ΔdprA mutant compared to the wildtype

Genes	Protein name/function	Protein fold change
holA ^a	DNA polymerase III δ-subunit	−22.66
recA ^a	Recombinase protein	−14.67
ftsK2	DNA translocase	−13.05
recN	DNA repair protein	−12.33
gyrA	DNA gyrase subunit A	−11.68
mutS	DNA mismatch repair protein	−11.59
topA	DNA topoisomerase 1	−10.19
dnaQ-2	DNA polymerase III ε-subunit	−7.30
dnaB	Replicative DNA helicase	−4.75
dnaN	DNA polymerase III β-subunit	−4.59
rmuC	DNA recombination protein RmuC homolog	−4.15
ruvB	ATP-dependent DNA helicase	−3.68
gyrB	DNA gyrase subunit B	−2.33
uvrD ^a	DNA helicase	−1.78
ftsK1	DNA translocase	−1.60
rdgC	Recombination-associated protein	−1.52
polA	DNA polymerase I	−1.48
ruvA	ATP-dependent DNA helicase	−1.47
dnaX	DNA polymerase III subunits γ and τ	+2.07
ssb	Single-stranded DNA-binding protein	+2.37
hupB	DNA-binding protein HU-β	+4.27

^aSignificantly regulated proteins. The minus sign of the protein fold change indicates the downregulated whereas the positive sign indicates upregulated proteins

ISSN: 1471-2180