Fig. 6.
From: Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
Chlamydia enhance self-peptide presentation in a LOS-dependant mechanism: a. L2 infected cells were treated with mock, sub-MEC and MEC concentrations of LPC. At the MEC of LPC (1.92 μg/mL) surface HLA-A2-SVG were reduced to mock-infected levels. A lower concentration of 0.5 μg/mL LPC did not rescue increased surface HLA-A2-SVG phenotype. b. Similar to (a), C. trachomatis L2-infected cells were either treated with ampicillin (10 µg/mL) or mock-treated and surface HLA-A2-SVG complexes were measured. c. Surface levels of HLA-A2-SVG were increased during C. caviae infection which was abrogated by treatment with LPC (2 μg/m). The same results were true for C. muridarum (d), C. abortus (e), and C. suis (f) (*, P < 0.05)